Genomic actions of estrogen receptor α: What are the targets and how are they regulated?

Willem Jan Welboren, Fred C.G.J. Sweep, Paul N. Span, Hendrik G. Stunnenberg

Research output: Contribution to journalReview articlepeer-review

127 Citations (Scopus)

Abstract

The estrogen receptor α (ERα) is a ligand-dependent transcription factor that regulates a large number of genes in many different target tissues and is important in the development and progression of breast cancer. ERα-mediated transcription is a complex process regulated at many different levels. The interplay between ligand, receptor, DNA sequence, cofactors, chromatin context, and post-translational modifications culminates in transcriptional regulation by ERα. Recent technological advances have allowed the identification of ERα target genes on a genomewide scale. In this review, we provide an overview of the progress made in our understanding of the different levels of regulation mediated by ERα. We discuss the recent advances in the identification of the ERα-binding sites and target gene network and their clinical applications.

Original languageEnglish
Pages (from-to)1073-1089
Number of pages17
JournalEndocrine-Related Cancer
Volume16
Issue number4
DOIs
Publication statusPublished - Dec 2009
Externally publishedYes

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