TY - JOUR
T1 - Genomic evolution from primary breast carcinoma to distant metastasis
T2 - Few copy number changes of breast cancer related genes
AU - Moelans, Cathy B.
AU - van der Groep, Petra
AU - Hoefnagel, Laurien D.C.
AU - van de Vijver, Marc J.
AU - Wesseling, Pieter
AU - Wesseling, Jelle
AU - van der Wall, Elsken
AU - van Diest, Paul J.
N1 - Funding Information:
This study was supported by grant UU 2011-5195 of the Dutch Cancer Society (with no involvement in study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication).
PY - 2014/3/1
Y1 - 2014/3/1
N2 - Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.
AB - Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.
KW - Breast cancer
KW - Gene dosage
KW - Metastases
KW - MLPA
UR - http://www.scopus.com/inward/record.url?scp=84893696572&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2013.10.025
DO - 10.1016/j.canlet.2013.10.025
M3 - Article
C2 - 24184827
AN - SCOPUS:84893696572
SN - 0304-3835
VL - 344
SP - 138
EP - 146
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -