Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes

Cathy B. Moelans; Petra van der Groep; Laurien D.C. Hoefnagel; Marc J. van de Vijver; Pieter Wesseling; Jelle Wesseling; Elsken van der Wall; Paul J. van Diest

doi:10.1016/j.canlet.2013.10.025

Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes

Cathy B. Moelans
, Petra van der Groep
, Laurien D.C. Hoefnagel
, Marc J. van de Vijver
, Pieter Wesseling
, Jelle Wesseling
, Elsken van der Wall
, Paul J. van Diest

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.

Original language	English
Pages (from-to)	138-146
Number of pages	9
Journal	Cancer Letters
Volume	344
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2013.10.025
Publication status	Published - 1 Mar 2014
Externally published	Yes

Keywords

Breast cancer
Gene dosage
Metastases
MLPA

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10.1016/j.canlet.2013.10.025

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title = "Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes",

abstract = "Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.",

keywords = "Breast cancer, Gene dosage, Metastases, MLPA",

author = "Moelans, \{Cathy B.\} and \{van der Groep\}, Petra and Hoefnagel, \{Laurien D.C.\} and \{van de Vijver\}, \{Marc J.\} and Pieter Wesseling and Jelle Wesseling and \{van der Wall\}, Elsken and \{van Diest\}, \{Paul J.\}",

note = "Funding Information: This study was supported by grant UU 2011-5195 of the Dutch Cancer Society (with no involvement in study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication). ",

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doi = "10.1016/j.canlet.2013.10.025",

language = "English",

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journal = "Cancer Letters",

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T2 - Few copy number changes of breast cancer related genes

AU - Moelans, Cathy B.

AU - van der Groep, Petra

AU - Hoefnagel, Laurien D.C.

AU - van de Vijver, Marc J.

AU - Wesseling, Pieter

AU - Wesseling, Jelle

AU - van der Wall, Elsken

AU - van Diest, Paul J.

N1 - Funding Information: This study was supported by grant UU 2011-5195 of the Dutch Cancer Society (with no involvement in study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication).

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.

AB - Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.

KW - Breast cancer

KW - Gene dosage

KW - Metastases

KW - MLPA

UR - https://www.scopus.com/pages/publications/84893696572

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DO - 10.1016/j.canlet.2013.10.025

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AN - SCOPUS:84893696572

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SP - 138

EP - 146

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes

Abstract

Keywords

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