Germ cell tumors: Pathology and genetics

J. W. Oosterhuis; Leendert H.J. Looijenga

doi:10.1016/B978-0-12-801238-3.66150-0

Germ cell tumors: Pathology and genetics

J. W. Oosterhuis
, Leendert H.J. Looijenga

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Citations (Scopus)

Abstract

Germ cell tumors (GCT) are a heterogeneous family of gonadal and extragonadal tumors derived from germ cells, and their precursors: primordial germ cells (PGC) and gonocytes. The wide range of clinical manifestations of GCT is due to the different developmental potential and anatomical sites of the originating cells. Consistent with most GCT being caused by disturbed development, genetic changes are usually not the initiators of neoplastic transformation, but rather progression-related. Familial occurrence and multiplicity of GCT is likely explained by predisposing genetic factors interacting with environmental cues. Germ cell- and embryonic characteristics of DNA-repair of the tumor stem cells explain the exquisite sensitivity of GCT for DNA-damaging agents.

Original language	English
Title of host publication	Encyclopedia of Cancer, Third Edition
Subtitle of host publication	Volumes 1-3
Publisher	Elsevier
Pages	121-153
Number of pages	33
Volume	2
ISBN (Electronic)	9780128124840
ISBN (Print)	9780128124857
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.66150-0
Publication status	Published - 1 Jan 2018
Externally published	Yes

Keywords

2C-State
Anatomical localization
Classification
Epidemiology
Genetics
Genomic imprinting
Germ cell tumor
Gonocyte
Induced pluripotency
Naïve-state
Pathogenesis
Pathology
Primed-state
Primordial germ cell
Reprogramming

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10.1016/B978-0-12-801238-3.66150-0

Cite this

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title = "Germ cell tumors: Pathology and genetics",

abstract = "Germ cell tumors (GCT) are a heterogeneous family of gonadal and extragonadal tumors derived from germ cells, and their precursors: primordial germ cells (PGC) and gonocytes. The wide range of clinical manifestations of GCT is due to the different developmental potential and anatomical sites of the originating cells. Consistent with most GCT being caused by disturbed development, genetic changes are usually not the initiators of neoplastic transformation, but rather progression-related. Familial occurrence and multiplicity of GCT is likely explained by predisposing genetic factors interacting with environmental cues. Germ cell- and embryonic characteristics of DNA-repair of the tumor stem cells explain the exquisite sensitivity of GCT for DNA-damaging agents.",

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year = "2018",

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T2 - Pathology and genetics

AU - Oosterhuis, J. W.

AU - Looijenga, Leendert H.J.

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Y1 - 2018/1/1

N2 - Germ cell tumors (GCT) are a heterogeneous family of gonadal and extragonadal tumors derived from germ cells, and their precursors: primordial germ cells (PGC) and gonocytes. The wide range of clinical manifestations of GCT is due to the different developmental potential and anatomical sites of the originating cells. Consistent with most GCT being caused by disturbed development, genetic changes are usually not the initiators of neoplastic transformation, but rather progression-related. Familial occurrence and multiplicity of GCT is likely explained by predisposing genetic factors interacting with environmental cues. Germ cell- and embryonic characteristics of DNA-repair of the tumor stem cells explain the exquisite sensitivity of GCT for DNA-damaging agents.

AB - Germ cell tumors (GCT) are a heterogeneous family of gonadal and extragonadal tumors derived from germ cells, and their precursors: primordial germ cells (PGC) and gonocytes. The wide range of clinical manifestations of GCT is due to the different developmental potential and anatomical sites of the originating cells. Consistent with most GCT being caused by disturbed development, genetic changes are usually not the initiators of neoplastic transformation, but rather progression-related. Familial occurrence and multiplicity of GCT is likely explained by predisposing genetic factors interacting with environmental cues. Germ cell- and embryonic characteristics of DNA-repair of the tumor stem cells explain the exquisite sensitivity of GCT for DNA-damaging agents.

KW - 2C-State

KW - Anatomical localization

KW - Classification

KW - Epidemiology

KW - Genetics

KW - Genomic imprinting

KW - Germ cell tumor

KW - Gonocyte

KW - Induced pluripotency

KW - Naïve-state

KW - Pathogenesis

KW - Pathology

KW - Primed-state

KW - Primordial germ cell

KW - Reprogramming

UR - https://www.scopus.com/pages/publications/85078581734

U2 - 10.1016/B978-0-12-801238-3.66150-0

DO - 10.1016/B978-0-12-801238-3.66150-0

M3 - Chapter

AN - SCOPUS:85078581734

SN - 9780128124857

VL - 2

SP - 121

EP - 153

BT - Encyclopedia of Cancer, Third Edition

PB - Elsevier

ER -

Germ cell tumors: Pathology and genetics

Abstract

Keywords

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