Germ cell tumours in neonates and infants: a distinct subgroup?

Imke M Veltman; Marga T Schepens; Leendert H J Looijenga; Louise C Strong; Ad Geurts van Kessel

doi:10.1034/j.1600-0463.2003.1110119_1.x

Germ cell tumours in neonates and infants: a distinct subgroup?

Imke M Veltman, Marga T Schepens, Leendert H J Looijenga, Louise C Strong, Ad Geurts van Kessel

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

Abstract

Human germ cell tumours (GCTs) constitute a heterogeneous group of tumours that can be classified into four major subgroups. One of these subgroups encompasses (immature) teratomas and yolk sac tumours of patients under the age of 5 years. In this paper we review the various clinical, histological and cytogenetical aspects of these infantile GCTs. The primordial germ cell (PGC) has been suggested to be the cell of origin for GCTs. Infantile GCTs, however, have been suggested to originate from PGCs at a different stage of maturation than adult GCTs. The cytogenetic constitution of infantile GCTs also appears to differ from the adult GCTs and includes recurrent losses of lp and 6q. Recently, two cases of infantile GCT were detected with constitutional 12q13 translocations. These exceptional cases may be instrumental in the search for candidate genes related to infantile and/or adult GCT development.

Original language	English
Pages (from-to)	152-60; discussion 160
Journal	APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Volume	111
Issue number	1
DOIs	https://doi.org/10.1034/j.1600-0463.2003.1110119_1.x
Publication status	Published - Jan 2003
Externally published	Yes

Keywords

Chromosome Aberrations
Chromosome Mapping
Chromosomes, Human, Pair 12
Germinoma/epidemiology
Humans
Infant
Infant, Newborn
Karyotyping
Male
Sacrococcygeal Region
Teratoma/epidemiology
Translocation, Genetic

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title = "Germ cell tumours in neonates and infants: a distinct subgroup?",

abstract = "Human germ cell tumours (GCTs) constitute a heterogeneous group of tumours that can be classified into four major subgroups. One of these subgroups encompasses (immature) teratomas and yolk sac tumours of patients under the age of 5 years. In this paper we review the various clinical, histological and cytogenetical aspects of these infantile GCTs. The primordial germ cell (PGC) has been suggested to be the cell of origin for GCTs. Infantile GCTs, however, have been suggested to originate from PGCs at a different stage of maturation than adult GCTs. The cytogenetic constitution of infantile GCTs also appears to differ from the adult GCTs and includes recurrent losses of lp and 6q. Recently, two cases of infantile GCT were detected with constitutional 12q13 translocations. These exceptional cases may be instrumental in the search for candidate genes related to infantile and/or adult GCT development.",

keywords = "Chromosome Aberrations, Chromosome Mapping, Chromosomes, Human, Pair 12, Germinoma/epidemiology, Humans, Infant, Infant, Newborn, Karyotyping, Male, Sacrococcygeal Region, Teratoma/epidemiology, Translocation, Genetic",

author = "Veltman, {Imke M} and Schepens, {Marga T} and Looijenga, {Leendert H J} and Strong, {Louise C} and {van Kessel}, {Ad Geurts}",

year = "2003",

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doi = "10.1034/j.1600-0463.2003.1110119_1.x",

language = "English",

volume = "111",

pages = "152--60; discussion 160",

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T1 - Germ cell tumours in neonates and infants

T2 - a distinct subgroup?

AU - Veltman, Imke M

AU - Schepens, Marga T

AU - Looijenga, Leendert H J

AU - Strong, Louise C

AU - van Kessel, Ad Geurts

PY - 2003/1

Y1 - 2003/1

N2 - Human germ cell tumours (GCTs) constitute a heterogeneous group of tumours that can be classified into four major subgroups. One of these subgroups encompasses (immature) teratomas and yolk sac tumours of patients under the age of 5 years. In this paper we review the various clinical, histological and cytogenetical aspects of these infantile GCTs. The primordial germ cell (PGC) has been suggested to be the cell of origin for GCTs. Infantile GCTs, however, have been suggested to originate from PGCs at a different stage of maturation than adult GCTs. The cytogenetic constitution of infantile GCTs also appears to differ from the adult GCTs and includes recurrent losses of lp and 6q. Recently, two cases of infantile GCT were detected with constitutional 12q13 translocations. These exceptional cases may be instrumental in the search for candidate genes related to infantile and/or adult GCT development.

AB - Human germ cell tumours (GCTs) constitute a heterogeneous group of tumours that can be classified into four major subgroups. One of these subgroups encompasses (immature) teratomas and yolk sac tumours of patients under the age of 5 years. In this paper we review the various clinical, histological and cytogenetical aspects of these infantile GCTs. The primordial germ cell (PGC) has been suggested to be the cell of origin for GCTs. Infantile GCTs, however, have been suggested to originate from PGCs at a different stage of maturation than adult GCTs. The cytogenetic constitution of infantile GCTs also appears to differ from the adult GCTs and includes recurrent losses of lp and 6q. Recently, two cases of infantile GCT were detected with constitutional 12q13 translocations. These exceptional cases may be instrumental in the search for candidate genes related to infantile and/or adult GCT development.

KW - Chromosome Aberrations

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 12

KW - Germinoma/epidemiology

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Karyotyping

KW - Male

KW - Sacrococcygeal Region

KW - Teratoma/epidemiology

KW - Translocation, Genetic

U2 - 10.1034/j.1600-0463.2003.1110119_1.x

DO - 10.1034/j.1600-0463.2003.1110119_1.x

M3 - Review article

C2 - 12752256

SN - 0903-4641

VL - 111

SP - 152-60; discussion 160

JO - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

IS - 1

ER -

Germ cell tumours in neonates and infants: a distinct subgroup?

Abstract

Keywords

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