Gonadal dysgenesis in disorders of sex development: Diagnosis and surgical management

K P Wolffenbuttel; R Hersmus; H Stoop; K Biermann; P Hoebeke; M Cools; L H J Looijenga

doi:10.1016/j.jpurol.2016.08.015

Gonadal dysgenesis in disorders of sex development: Diagnosis and surgical management

K P Wolffenbuttel, R Hersmus, H Stoop, K Biermann, P Hoebeke, M Cools, L H J Looijenga

Research output: Contribution to journal › Review article › peer-review

59 Citations (Scopus)

Abstract

Recent studies on gonadal histology have improved the understanding of germ cell malignancy risk in patients with disorders of sex development (DSD), and evidence-based gonadal management strategies are gradually emerging. Especially in 46,XY DSD and 45,X/46,XY DSD, which are characterized by gonadal dysgenesis, the risk of germ cell malignancy is significantly increased. This paper summarized the progress over the past 10 years in malignancy risk assessment in patients with DSD, and its implications for optimal surgical handling of the involved gonads.

Original language	English
Pages (from-to)	411-416
Number of pages	6
Journal	Journal of pediatric urology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/j.jpurol.2016.08.015
Publication status	Published - Dec 2016
Externally published	Yes

Keywords

Child
Decision Trees
Female
Gonadal Dysgenesis/diagnosis
Humans
Male
Urologic Surgical Procedures/methods

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10.1016/j.jpurol.2016.08.015

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title = "Gonadal dysgenesis in disorders of sex development: Diagnosis and surgical management",

abstract = "Recent studies on gonadal histology have improved the understanding of germ cell malignancy risk in patients with disorders of sex development (DSD), and evidence-based gonadal management strategies are gradually emerging. Especially in 46,XY DSD and 45,X/46,XY DSD, which are characterized by gonadal dysgenesis, the risk of germ cell malignancy is significantly increased. This paper summarized the progress over the past 10 years in malignancy risk assessment in patients with DSD, and its implications for optimal surgical handling of the involved gonads.",

keywords = "Child, Decision Trees, Female, Gonadal Dysgenesis/diagnosis, Humans, Male, Urologic Surgical Procedures/methods",

author = "Wolffenbuttel, {K P} and R Hersmus and H Stoop and K Biermann and P Hoebeke and M Cools and Looijenga, {L H J}",

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T2 - Diagnosis and surgical management

AU - Wolffenbuttel, K P

AU - Hersmus, R

AU - Stoop, H

AU - Biermann, K

AU - Hoebeke, P

AU - Cools, M

AU - Looijenga, L H J

PY - 2016/12

Y1 - 2016/12

N2 - Recent studies on gonadal histology have improved the understanding of germ cell malignancy risk in patients with disorders of sex development (DSD), and evidence-based gonadal management strategies are gradually emerging. Especially in 46,XY DSD and 45,X/46,XY DSD, which are characterized by gonadal dysgenesis, the risk of germ cell malignancy is significantly increased. This paper summarized the progress over the past 10 years in malignancy risk assessment in patients with DSD, and its implications for optimal surgical handling of the involved gonads.

AB - Recent studies on gonadal histology have improved the understanding of germ cell malignancy risk in patients with disorders of sex development (DSD), and evidence-based gonadal management strategies are gradually emerging. Especially in 46,XY DSD and 45,X/46,XY DSD, which are characterized by gonadal dysgenesis, the risk of germ cell malignancy is significantly increased. This paper summarized the progress over the past 10 years in malignancy risk assessment in patients with DSD, and its implications for optimal surgical handling of the involved gonads.

KW - Child

KW - Decision Trees

KW - Female

KW - Gonadal Dysgenesis/diagnosis

KW - Humans

KW - Male

KW - Urologic Surgical Procedures/methods

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DO - 10.1016/j.jpurol.2016.08.015

M3 - Review article

C2 - 27769830

SN - 1477-5131

VL - 12

SP - 411

EP - 416

JO - Journal of pediatric urology

JF - Journal of pediatric urology

IS - 6

ER -

Gonadal dysgenesis in disorders of sex development: Diagnosis and surgical management

Abstract

Keywords

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