Gonadal tumours and DSD

Leendert H J Looijenga, Remko Hersmus, Bertie H C G M de Leeuw, Hans Stoop, Martine Cools, J Wolter Oosterhuis, Stenvert L S Drop, Katja P Wolffenbuttel

Research output: Contribution to journalReview articlepeer-review

99 Citations (Scopus)

Abstract

Disorders of sex development (DSD), previously referred to as intersex, has been recognised as one of the main risk factors for development of type II germ cell tumours (GCTs), that is, seminomas/dysgerminomas and non-seminomas (e.g., embryonal carcinoma, yolk sac tumour, choriocarcinoma and teratoma). Within the testis, this type of cancer is the most frequent malignancy in adolescent and young adult Caucasian males. Although these males are not known to have dysgenetic gonads, the similarities in the resulting tumours suggest a common aetiological mechanism(s),--genetically, environmentally or a combination of both. Within the group of DSD patients, being in fact congenital conditions, the risk of malignant transformation of germ cells is highly heterogeneous, depending on a number of parameters, some of which have only recently been identified. Understanding of these recent insights will stimulate further research, with the final aim to develop an informative clinical decision tree for DSD patients, which includes optimal (early) diagnosis without overtreatment, such as prophylactic gonadectomy in the case of a low tumour risk.

Original languageEnglish
Pages (from-to)291-310
Number of pages20
JournalBest practice & research. Clinical endocrinology & metabolism
Volume24
Issue number2
DOIs
Publication statusPublished - Apr 2010
Externally publishedYes

Keywords

  • Adolescent
  • Adult
  • Denys-Drash Syndrome/genetics
  • Disorders of Sex Development/complications
  • Germ Cells/growth & development
  • Gonadal Dysgenesis/pathology
  • Gonads/embryology
  • Humans
  • Male
  • Neoplasms, Germ Cell and Embryonal/etiology
  • Risk Factors
  • SOXB1 Transcription Factors/genetics
  • Seminoma/pathology
  • Teratoma/pathology
  • Testicular Neoplasms/pathology

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