Hearing and Other Neurologic Problems

Wendy Landier, Richard J. Cohn, Marry M. van den Heuvel-Eibrink

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Ototoxicity and other neurologic toxicities are potential consequences of exposure to common therapeutic agents used during treatment of childhood cancer, including platinum and vinca alkaloid chemotherapy, cranial radiation, surgery involving structures critical to cochlear and neurologic function, and supportive care medications such as aminoglycoside antibiotics and loop diuretics. This article provides an overview of ototoxicity and other neurologic toxicities related to childhood cancer treatment, discusses the challenges that these toxicities may pose for survivors, and presents an overview of current recommendations for surveillance and clinical management of these potentially life-altering toxicities in survivors of childhood cancers.

Original languageEnglish
Pages (from-to)1219-1235
Number of pages17
JournalPediatric Clinics of North America
Issue number6
Publication statusPublished - Dec 2020


  • Antineoplastic therapy
  • Management
  • Motor deficits
  • Otoprotection
  • Ototoxicity
  • Peripheral neuropathy
  • Seizures
  • Surveillance


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