HMG box containing transcription factors in lymphocyte differentiation

Marco W. Schilham, Hans Clevers

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


The identifcation of the mammalian sex-determining gene Sry has led to the discovery of a large family of related ('HMG box') transcription factors that control developmental events in yeast, C. elegans, Drosophila and vertebrates. In lymphocyte differentiation, several HMG box proteins play a decisive role. Sox-4 is important for very early B-cell differentiation, while TCF-1/LEF-1 play a crucial role in early thymocyte development. TCF/LEF proteins have recently been found to constitute a downstream component of the Wingless/Wnt signal transduction pathway. In flies, this pathway controls segment polarity; in Xenopus it controls the definition of the body axis. Deregulation of the pathway occurs in several human tumors. These insights in the molecular events that are involved in TCF/LEF function in these organisms may eventually lead to the under standing of the function of these HMG box proteins in lymphoid development.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalSeminars in Immunology
Issue number2
Publication statusPublished - Apr 1998
Externally publishedYes


  • LEF
  • Lymphocytes
  • SOX
  • TCF
  • Wingless
  • WNT


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