HORMA domains at the heart of meiotic chromosome dynamics

Gerben Vader; Andrea Musacchio

doi:10.1016/j.devcel.2014.11.009

HORMA domains at the heart of meiotic chromosome dynamics

Gerben Vader
, Andrea Musacchio

Research output: Contribution to journal › Article › peer-review

Abstract

HORMA domain proteins are required for the careful orchestration of chromosomal organization during meiosis. Kim et al. (2014) and Silva et al. (2014) now provide structural and functional insights into the roles of C. elegans HORMA proteins, revealing parallels to the function of the HORMA protein MAD2 in mitotic checkpoint signaling.

Original language	English
Pages (from-to)	389-91
Number of pages	3
Journal	Developmental Cell
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/j.devcel.2014.11.009
Publication status	Published - 24 Nov 2014
Externally published	Yes

Keywords

Animals
Caenorhabditis elegans/metabolism
Caenorhabditis elegans Proteins/metabolism
Cell Cycle Proteins/metabolism
Chromosome Pairing/genetics
Chromosomes/metabolism
Meiosis/physiology
Signal Transduction/physiology
Synaptonemal Complex/metabolism

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10.1016/j.devcel.2014.11.009

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title = "HORMA domains at the heart of meiotic chromosome dynamics",

abstract = "HORMA domain proteins are required for the careful orchestration of chromosomal organization during meiosis. Kim et al. (2014) and Silva et al. (2014) now provide structural and functional insights into the roles of C. elegans HORMA proteins, revealing parallels to the function of the HORMA protein MAD2 in mitotic checkpoint signaling.",

keywords = "Animals, Caenorhabditis elegans/metabolism, Caenorhabditis elegans Proteins/metabolism, Cell Cycle Proteins/metabolism, Chromosome Pairing/genetics, Chromosomes/metabolism, Meiosis/physiology, Signal Transduction/physiology, Synaptonemal Complex/metabolism",

author = "Gerben Vader and Andrea Musacchio",

year = "2014",

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doi = "10.1016/j.devcel.2014.11.009",

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AU - Musacchio, Andrea

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AB - HORMA domain proteins are required for the careful orchestration of chromosomal organization during meiosis. Kim et al. (2014) and Silva et al. (2014) now provide structural and functional insights into the roles of C. elegans HORMA proteins, revealing parallels to the function of the HORMA protein MAD2 in mitotic checkpoint signaling.

KW - Animals

KW - Caenorhabditis elegans/metabolism

KW - Caenorhabditis elegans Proteins/metabolism

KW - Cell Cycle Proteins/metabolism

KW - Chromosome Pairing/genetics

KW - Chromosomes/metabolism

KW - Meiosis/physiology

KW - Signal Transduction/physiology

KW - Synaptonemal Complex/metabolism

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DO - 10.1016/j.devcel.2014.11.009

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SN - 1534-5807

VL - 31

SP - 389

EP - 391

JO - Developmental Cell

JF - Developmental Cell

IS - 4

ER -

HORMA domains at the heart of meiotic chromosome dynamics

Abstract

Keywords

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