Human-Derived Model Systems in Gynecological Cancer Research

Kadi Lõhmussaar, Matteo Boretto, Hans Clevers

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


The human female reproductive tract (FRT) is a complex system that combines series of organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which possesses unique cellular characteristics and functions. This versatility, in turn, allows for the development of a wide range of epithelial gynecological cancers with distinct features. Thus, reliable model systems are required to better understand the diverse mechanisms involved in the regional pathogenesis of the reproductive tract and improve treatment strategies. Here, we review the current human-derived model systems available to study the multitude of gynecological cancers, including ovarian, endometrial, cervical, vaginal, and vulvar cancer, and the recent advances in the push towards personalized therapy.

Original languageEnglish
Pages (from-to)1031-1043
Number of pages13
JournalTrends in Cancer
Issue number12
Publication statusPublished - Dec 2020
Externally publishedYes


  • cancer modeling
  • gynecology
  • human papillomavirus
  • organoids


Dive into the research topics of 'Human-Derived Model Systems in Gynecological Cancer Research'. Together they form a unique fingerprint.

Cite this