Human papillomavirus, lichen sclerosus, and squamous cell carcinoma of the vulva: Detection and prognostic significance

Anca C. Ansink, Mark R.L. Krul, Roel A. De Weger, John A.F.W. Kleyne, Helga Pijpers, Harm Van Tinteren, Elly W. De Kraker, Theo J.M. Helmerhorst, A. Peter M. Heintz

Research output: Contribution to journalArticlepeer-review

108 Citations (Scopus)

Abstract

Detection of HPV-DNA in squamous vulvar carcinoma, its prognostic significance, and investigation of the presence of lichen sclerosus near HPV- DNA-positive vulvar carcinomas were the objectives of this study. In 60 samples of squamous vulvar cancer, we looked for HPV-DNA by means of PCR. The same samples were examined for the presence of lichen sclerosus. The possible prognostic significance of the presence of HPV-DNA and lichen sclerosus was studied. Nineteen (32%) of the samples were HPV-DNA positive using PCR. Patients with an HPV-positive tumor had a better prognosis than those with an HPV-negative tumor (P = 0.03). Lichen sclerosus was found in 19 tumor samples, of which 7 had detectable HPV-DNA. Only a minority of vulvar cancers contain HPV-DNA. In contrast to previous statements, near some of these HPV- positive cancers, lichen sclerosus can be found.

Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalGynecologic Oncology
Volume52
Issue number2
DOIs
Publication statusPublished - Feb 1994
Externally publishedYes

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