Human tissue kallikreins and testicular cancer

Liu Ying Luo, George Yousef, Eleftherios P. Diamandis, Leendert Looijenga, Anders Bjartell

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Human tissue kallikreins are fifteen homologous genes encoding for secreted serine proteases and residing tandemly on chromosome 19q13.4. These enzymes are highly expressed in a variety of tissues and participate in diverse physiological processes. Human tissue kallikreins were found to be associated with several malignancies, especially endocrine-related cancers, including prostate, ovarian, breast and testicular cancer. In testicular germ cell tumors, some tissue kallikrein genes, including KLK5, KLK10, KLK13 and KLK14, were found to be significantly down-regulated. Tissue-specific splice variant forms of some kallikreins have been identified in the testis. In this paper, the expression of KLK5, KLK10, KLK13 and KLK14 in testicular cancer and their possible roles during testicular cancer development, as well as their clinical applications are briefly reviewed.

Original languageEnglish
Pages (from-to)225-233
Number of pages9
JournalAPMIS
Volume111
Issue number1
DOIs
Publication statusPublished - 1 Jan 2003
Externally publishedYes

Keywords

  • Human tissue kallikreins
  • Prognostic markers
  • Splice variants
  • Testicular cancer
  • Tissue-specific expression
  • Tumor markers

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