Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients

Yadi Huang; Anne Boerema-de Munck; Marjon Buscop-van Kempen; Ilona Sluiter; Ronald de Krijger; Dick Tibboel; Robbert J. Rottier

doi:10.1177/2045894018783734

Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients

Yadi Huang, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Ilona Sluiter, Ronald de Krijger, Dick Tibboel, Robbert J. Rottier

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Abstract

We show that hypoxia inducible factor 2α (HIF2α) is highly expressed in patients with pulmonary hypertension (PH). HIF2α is expressed in every patient with congenital diaphragmatic hernia, while only half of the controls express HIF2α. Our data suggest that HIF2α is a link between hypoxia and the development of PH.

Original language	English
Journal	Pulmonary Circulation
Volume	8
Issue number	3
DOIs	https://doi.org/10.1177/2045894018783734
Publication status	Published - 1 Jul 2018

Keywords

hypoxia inducible factor
pulmonary hypertension
pulmonary vascular development and epithelium

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10.1177/2045894018783734

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title = "Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients",

abstract = "We show that hypoxia inducible factor 2α (HIF2α) is highly expressed in patients with pulmonary hypertension (PH). HIF2α is expressed in every patient with congenital diaphragmatic hernia, while only half of the controls express HIF2α. Our data suggest that HIF2α is a link between hypoxia and the development of PH.",

keywords = "hypoxia inducible factor, pulmonary hypertension, pulmonary vascular development and epithelium",

author = "Yadi Huang and {Boerema-de Munck}, Anne and {Buscop-van Kempen}, Marjon and Ilona Sluiter and {de Krijger}, Ronald and Dick Tibboel and Rottier, {Robbert J.}",

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AU - Huang, Yadi

AU - Boerema-de Munck, Anne

AU - Buscop-van Kempen, Marjon

AU - Sluiter, Ilona

AU - de Krijger, Ronald

AU - Tibboel, Dick

AU - Rottier, Robbert J.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - We show that hypoxia inducible factor 2α (HIF2α) is highly expressed in patients with pulmonary hypertension (PH). HIF2α is expressed in every patient with congenital diaphragmatic hernia, while only half of the controls express HIF2α. Our data suggest that HIF2α is a link between hypoxia and the development of PH.

AB - We show that hypoxia inducible factor 2α (HIF2α) is highly expressed in patients with pulmonary hypertension (PH). HIF2α is expressed in every patient with congenital diaphragmatic hernia, while only half of the controls express HIF2α. Our data suggest that HIF2α is a link between hypoxia and the development of PH.

KW - hypoxia inducible factor

KW - pulmonary hypertension

KW - pulmonary vascular development and epithelium

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U2 - 10.1177/2045894018783734

DO - 10.1177/2045894018783734

M3 - Article

AN - SCOPUS:85055058533

SN - 2045-8932

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JO - Pulmonary Circulation

JF - Pulmonary Circulation

IS - 3

ER -

Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients

Abstract

Keywords

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