TY - JOUR
T1 - Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma
AU - Oosterhuis, J. Wolter
AU - de Jong, Bauke
AU - van Dalen, Ineke
AU - van der Meer, Ingrid
AU - Visser, Margreet
AU - de Leij, Loe
AU - Mesander, Geert
AU - Collard, John G.
AU - Koops, Heimen Schraffordt
AU - Sleijfer, Dirk Th
N1 - Funding Information:
Supported in part by Grant GUCK 83-4 from The Netherlands Cancer Foundation (Koningin Wilhelmina Fends).
PY - 1985/2/1
Y1 - 1985/2/1
N2 - A 39-year-old white male presented with a disseminated mediastinal teratocarcinoma. Karyotyping was performed on two mature residual metastatic lesions in the lungs immediately following chemotherapy, on a recurring lung lesion after 5 months, and on a metastasis in the right thigh 5 months after salvage chemotherapy. All four lesions were pseudoeuploid and showed identical chromosomal abnormalities: a translocation with the two chromosomes #6 and one chromosome #11 involved, resulting in 46, XY, t (6;6;11) (q21;q23;q13). The breakpoint in chromosome #6 is in the region to which the oncogene c-myb has been localized, and the breakpoint in chromosome #11 is at a known fragile and possibly oncogenic site, suggesting that the translocations in this case may have played a crucial role in the development of the malignancy.
AB - A 39-year-old white male presented with a disseminated mediastinal teratocarcinoma. Karyotyping was performed on two mature residual metastatic lesions in the lungs immediately following chemotherapy, on a recurring lung lesion after 5 months, and on a metastasis in the right thigh 5 months after salvage chemotherapy. All four lesions were pseudoeuploid and showed identical chromosomal abnormalities: a translocation with the two chromosomes #6 and one chromosome #11 involved, resulting in 46, XY, t (6;6;11) (q21;q23;q13). The breakpoint in chromosome #6 is in the region to which the oncogene c-myb has been localized, and the breakpoint in chromosome #11 is at a known fragile and possibly oncogenic site, suggesting that the translocations in this case may have played a crucial role in the development of the malignancy.
UR - http://www.scopus.com/inward/record.url?scp=0021913327&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(85)90136-0
DO - 10.1016/0165-4608(85)90136-0
M3 - Article
C2 - 3967222
AN - SCOPUS:0021913327
SN - 0165-4608
VL - 15
SP - 99
EP - 107
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1-2
ER -