TY - JOUR
T1 - Identification of an immunogenic EWS-FLI1-derived HLA-DR-restricted T helper cell epitope
AU - Meyer-Wentrup, Friederike
AU - Richter, Günther
AU - Burdach, Stefan
N1 - Funding Information:
Received 18 August 2004; accepted 8 February 2005. This work was supported by the BMBF-Roux Research Program of the Martin-Luther-University Halle-Wittenberg, grant number FKZ 2/21, and the Deutsche Krebshilfe, grant number FKZ 70-2787-Bu3. Address correspondence to Friederike Meyer-Wentrup, MD, Children’s Cancer Research Center/Biocenter and Department of Pediatrics, Martin-Luther-University Halle-Wittenberg, 06097 Halle, Germany. E-mail: [email protected]
PY - 2005/6
Y1 - 2005/6
N2 - Immunotherapy with tumor-specific peptide-loaded dendritic cells represents a promising therapeutic approach for patients with multifocal primary or early relapsed Ewing family tumors (EFT). The authors therefore screened a peptide library derived from the fusion region of the EFT-specific chimeric transcription factor EWS-FLI1 for immunogenic peptides. T-cell priming with 10 peptides was evaluated using IFNγ video-assisted automated enzyme-linked immunospot technique. The authors report the identification of the first EFT-specific immunogenic T-cell epitope so far. Its identification will lead to a better understanding of EFT immunology and may improve DC-based immunotherapy.
AB - Immunotherapy with tumor-specific peptide-loaded dendritic cells represents a promising therapeutic approach for patients with multifocal primary or early relapsed Ewing family tumors (EFT). The authors therefore screened a peptide library derived from the fusion region of the EFT-specific chimeric transcription factor EWS-FLI1 for immunogenic peptides. T-cell priming with 10 peptides was evaluated using IFNγ video-assisted automated enzyme-linked immunospot technique. The authors report the identification of the first EFT-specific immunogenic T-cell epitope so far. Its identification will lead to a better understanding of EFT immunology and may improve DC-based immunotherapy.
KW - Dendritic cells
KW - Ewing family tumors
KW - Peptide epitope
KW - Tumor vaccination
UR - https://www.scopus.com/pages/publications/20044362414
U2 - 10.1080/08880010590935194
DO - 10.1080/08880010590935194
M3 - Article
C2 - 16020117
AN - SCOPUS:20044362414
SN - 0888-0018
VL - 22
SP - 297
EP - 308
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
IS - 4
ER -