IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study

Keyphrases

• Genome Sequencing 100%
• Sequencing Studies 100%
• Mutation Resistance 100%
• Receptor mutations 100%
• T-cell ALL 100%
• IL-7 Receptor 100%
• Steroid Resistance 100%
• Pediatric T-cell Acute Lymphoblastic Leukemia 100%
• Interleukin-7 Receptor 90%
• Receptor Signaling 63%
• Janus Kinase 1 (JAK1) 36%
• Steroid-sensitive 36%
• Poor Outcome 27%
• Acute Lymphoblastic Leukemia 27%
• Mammalian Target of Rapamycin (mTOR) 27%
• JAK3 27%
• Pediatric Acute Lymphoblastic Leukemia 18%
• Clinical Outcomes 18%
• Signaling Pathway 18%
• T Cells 18%
• Signaling Molecules 18%
• Induced Cell Death 18%
• Steroid-induced 18%
• Signal Transduction Inhibitors 18%
• Childhood Cancer 9%
• Clinical Significance 9%
• Cancer Mortality 9%
• Whole Genome Sequencing 9%
• L-asparaginase 9%
• Copy number 9%
• Functional Studies 9%
• MEK-ERK Pathway 9%
• Drug Response 9%
• Specific mutation 9%
• Sequence Method 9%
• Mutated Genes 9%
• Cancer Causes 9%
• T-cell Acute Lymphoblastic Leukemia (T-ALL) 9%
• Downstream Targets 9%
• Genetic Mechanism 9%
• Strongest Activations 9%
• Low Incidence 9%
• Cohort Size 9%
• Unbiased Sequencing 9%
• Pro-apoptotic 9%
• Steroid Receptors 9%
• Cellular Mechanisms 9%
• Genomic Datasets 9%
• Lentiviral Expression 9%
• Anti-apoptotic 9%
• Bcl-xL 9%
• Prospective Clinical Study 9%
• Resistance to Treatment 9%
• MEK-ERK 9%
• Early Thymic Progenitors 9%
• ALL Subtypes 9%
• Signaling Genes 9%
• Treatment-seeking Sample 9%
• High-risk Disease 9%
• Steroid Response 9%
• Treatment-free Remission 9%
• Mutation Data 9%
• Prednisolone 9%
• Myeloid Cell leukemia-1 (Mcl-1) 9%
• ALL Treatment 9%
• Expression Construct 9%
• AKT Pathway 9%
• Steroid Therapy 9%
• Gene Encoding 9%
• PI3K/mTOR Inhibitor 9%
• Integrated Dataset 9%
• Targeted Exome Sequencing 9%

Biochemistry, Genetics and Molecular Biology

• T Cell 100%
• Genome Sequencing 100%
• Interleukin 7 100%
• Pediatrics 100%
• Steroid 100%
• Interleukin-7 Receptor 50%
• Protein Kinase B 35%
• Mammalian Target of Rapamycin 20%
• Wild Type 15%
• Signal Transduction 15%
• KRAS 10%
• Cell Death 10%
• Whole Genome Sequencing 5%
• Asparaginase 5%
• Drug Response 5%
• Exome Sequencing 5%
• Mutated Genes 5%
• Clinical Study 5%
• Genetic Mechanism 5%
• Steroid Receptor 5%
• GSK3B 5%
• MCL1 5%
• Genomics 5%
• Prednisolone 5%

Immunology and Microbiology

• T Cell 100%
• Genome Sequencing 100%
• Interleukin 7 100%
• Steroid 100%
• Interleukin-7 Receptor 47%
• Wild Type 14%
• Signal Transduction 14%
• Cell Death 9%
• Cell Line 9%
• In Vitro 9%
• Pretreatment 9%
• Whole Genome Sequencing 4%
• Drug Response 4%
• Whole Exome Sequencing 4%
• Prednisolone 4%