Imaging features of hepatic sinusoidal obstruction syndrome or veno-occlusive disease in children

Anneloes E Bohte, Miranda P Dierselhuis, Max M van Noesel, Maarten H Lequin

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatic sinusoidal obstruction syndrome, also known as veno-occlusive disease, can occur as a complication of myeloablative chemotherapy, as a result of low-intensity chemotherapy-related liver toxicity or radiotherapy of the liver. Symptoms of sinusoidal obstruction syndrome can range from asymptomatic to liver dysfunction or severe disease with life-threatening acute multi-organ failure. Imaging features can suggest or support this clinical diagnosis. Familiarity with the imaging spectrum of sinusoidal obstruction syndrome is therefore important for both radiologists and clinical oncologists. Here, multi-modality radiologic appearances of sinusoidal obstruction syndrome in pediatric patients are illustrated, including outcome after follow-up.

Original languageEnglish
Pages (from-to)122-133
Number of pages12
JournalPediatric radiology
Volume52
Issue number1
DOIs
Publication statusPublished - Nov 2021

Keywords

  • Child
  • Hepatic Veno-Occlusive Disease/chemically induced
  • Humans

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