Immunostimulation versus immunosuppression after multiple vaccinations: The woes of therapeutic vaccine development

Research output: Contribution to journalComment/debate

25 Citations (Scopus)

Abstract

Three articles in this issue of Clinical Cancer Research show how multiple vaccinations can lead to immunosuppression. Moreover, two studies in patients show that granulocyte macrophage colony-stimulating factor (GM-CSF) as an adjuvant immunostimulant to different kind of vaccines can lead to adverse outcome in terms of relapse-free and overall survival. Modulation of regulatory T-cell activity may be required to overcome this outcome and may be crucial for the successful development of therapeutic vaccines.

Original languageEnglish
Pages (from-to)6745-6747
Number of pages3
JournalClinical Cancer Research
Volume15
Issue number22
DOIs
Publication statusPublished - 15 Nov 2009
Externally publishedYes

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