Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia

Ayami Yoshimi; Irith Baumann; Monika Führer; Eva Bergsträsser; Ulrich Göbel; Karl Walter Sykora; Thomas Klingebiel; Ute Gross-Wieltsch; Marry M. Van Den Heuvel-Eibrink; Alexandra Fischer; Peter Nöllke; Charlotte Niemeyer

doi:10.3324/haematol.10683

Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia

Ayami Yoshimi, Irith Baumann, Monika Führer, Eva Bergsträsser, Ulrich Göbel, Karl Walter Sykora, Thomas Klingebiel, Ute Gross-Wieltsch, Marry M. Van Den Heuvel-Eibrink, Alexandra Fischer, Peter Nöllke, Charlotte Niemeyer

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

It is currently unknown whether immunosuppressive therapy or hematopoietic stem cell transplantation is the most appropriate treatment strategy for children with refractory cytopenia and normal karyotype or trisomy 8. We report on 31 children with hypoplastic refractory cytopenia treated with immunosuppressive therapy consisting of antithymocyte globulin and cyclosporine. At 6 months, 22 of 29 evaluable patients had a complete or partial response; a total of ten patients achieved a complete response at varying time points. Six patients subsequently received a transplant because of non-response, progression to advanced myelodysplastic syndrome or evolution of monosomy 7. Overall and failure-free survival rates at 3 years were 88% and 57%, respectively.

Original language	English
Pages (from-to)	397-400
Number of pages	4
Journal	Haematologica
Volume	92
Issue number	3
DOIs	https://doi.org/10.3324/haematol.10683
Publication status	Published - Mar 2007
Externally published	Yes

Keywords

Anti-thymocyte globulin
Children
Immunosuppressive therapy
Myelodysplastic syndrome
Refractory cytopenia

Access to Document

10.3324/haematol.10683

Cite this

Yoshimi, A., Baumann, I., Führer, M., Bergsträsser, E., Göbel, U., Sykora, K. W., Klingebiel, T., Gross-Wieltsch, U., Van Den Heuvel-Eibrink, M. M., Fischer, A., Nöllke, P., & Niemeyer, C. (2007). Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia. Haematologica, 92(3), 397-400. https://doi.org/10.3324/haematol.10683

@article{13fa59cb1cad453c8d61c70473ff7149,

title = "Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia",

abstract = "It is currently unknown whether immunosuppressive therapy or hematopoietic stem cell transplantation is the most appropriate treatment strategy for children with refractory cytopenia and normal karyotype or trisomy 8. We report on 31 children with hypoplastic refractory cytopenia treated with immunosuppressive therapy consisting of antithymocyte globulin and cyclosporine. At 6 months, 22 of 29 evaluable patients had a complete or partial response; a total of ten patients achieved a complete response at varying time points. Six patients subsequently received a transplant because of non-response, progression to advanced myelodysplastic syndrome or evolution of monosomy 7. Overall and failure-free survival rates at 3 years were 88% and 57%, respectively.",

keywords = "Anti-thymocyte globulin, Children, Immunosuppressive therapy, Myelodysplastic syndrome, Refractory cytopenia",

author = "Ayami Yoshimi and Irith Baumann and Monika F{\"u}hrer and Eva Bergstr{\"a}sser and Ulrich G{\"o}bel and Sykora, {Karl Walter} and Thomas Klingebiel and Ute Gross-Wieltsch and {Van Den Heuvel-Eibrink}, {Marry M.} and Alexandra Fischer and Peter N{\"o}llke and Charlotte Niemeyer",

year = "2007",

month = mar,

doi = "10.3324/haematol.10683",

language = "English",

volume = "92",

pages = "397--400",

journal = "Haematologica",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

number = "3",

}

Yoshimi, A, Baumann, I, Führer, M, Bergsträsser, E, Göbel, U, Sykora, KW, Klingebiel, T, Gross-Wieltsch, U, Van Den Heuvel-Eibrink, MM, Fischer, A, Nöllke, P & Niemeyer, C 2007, 'Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia', Haematologica, vol. 92, no. 3, pp. 397-400. https://doi.org/10.3324/haematol.10683

TY - JOUR

T1 - Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia

AU - Yoshimi, Ayami

AU - Baumann, Irith

AU - Führer, Monika

AU - Bergsträsser, Eva

AU - Göbel, Ulrich

AU - Sykora, Karl Walter

AU - Klingebiel, Thomas

AU - Gross-Wieltsch, Ute

AU - Van Den Heuvel-Eibrink, Marry M.

AU - Fischer, Alexandra

AU - Nöllke, Peter

AU - Niemeyer, Charlotte

PY - 2007/3

Y1 - 2007/3

N2 - It is currently unknown whether immunosuppressive therapy or hematopoietic stem cell transplantation is the most appropriate treatment strategy for children with refractory cytopenia and normal karyotype or trisomy 8. We report on 31 children with hypoplastic refractory cytopenia treated with immunosuppressive therapy consisting of antithymocyte globulin and cyclosporine. At 6 months, 22 of 29 evaluable patients had a complete or partial response; a total of ten patients achieved a complete response at varying time points. Six patients subsequently received a transplant because of non-response, progression to advanced myelodysplastic syndrome or evolution of monosomy 7. Overall and failure-free survival rates at 3 years were 88% and 57%, respectively.

AB - It is currently unknown whether immunosuppressive therapy or hematopoietic stem cell transplantation is the most appropriate treatment strategy for children with refractory cytopenia and normal karyotype or trisomy 8. We report on 31 children with hypoplastic refractory cytopenia treated with immunosuppressive therapy consisting of antithymocyte globulin and cyclosporine. At 6 months, 22 of 29 evaluable patients had a complete or partial response; a total of ten patients achieved a complete response at varying time points. Six patients subsequently received a transplant because of non-response, progression to advanced myelodysplastic syndrome or evolution of monosomy 7. Overall and failure-free survival rates at 3 years were 88% and 57%, respectively.

KW - Anti-thymocyte globulin

KW - Children

KW - Immunosuppressive therapy

KW - Myelodysplastic syndrome

KW - Refractory cytopenia

UR - http://www.scopus.com/inward/record.url?scp=34247607821&partnerID=8YFLogxK

U2 - 10.3324/haematol.10683

DO - 10.3324/haematol.10683

M3 - Article

C2 - 17339190

AN - SCOPUS:34247607821

SN - 0390-6078

VL - 92

SP - 397

EP - 400

JO - Haematologica

JF - Haematologica

IS - 3

ER -

Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia

Abstract

Keywords

Access to Document

Fingerprint

Cite this