Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors

B. Van Etten; A. M.M. Eggermont; G. Ambagtsheer; S. T. Van Tiel; T. L.M. Ten Hagen

doi:10.1038/sj.bjc.6602151

Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors

B. Van Etten
, A. M.M. Eggermont
, G. Ambagtsheer
, S. T. Van Tiel
, T. L.M. Ten Hagen

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP, A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings.

Original language	English
Pages (from-to)	1610-1613
Number of pages	4
Journal	British journal of cancer
Volume	91
Issue number	8
DOIs	https://doi.org/10.1038/sj.bjc.6602151
Publication status	Published - 18 Oct 2004
Externally published	Yes

Keywords

Adenovirus
Antibodies
Gene therapy
Liver perfusion

Access to Document

10.1038/sj.bjc.6602151

Cite this

@article{05983ff37f954744ab6f8e6c91e1df42,

title = "Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors",

abstract = "Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP, A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings.",

keywords = "Adenovirus, Antibodies, Gene therapy, Liver perfusion",

author = "\{Van Etten\}, B. and Eggermont, \{A. M.M.\} and G. Ambagtsheer and \{Van Tiel\}, \{S. T.\} and \{Ten Hagen\}, \{T. L.M.\}",

year = "2004",

month = oct,

day = "18",

doi = "10.1038/sj.bjc.6602151",

language = "English",

volume = "91",

pages = "1610--1613",

journal = "British journal of cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "8",

}

TY - JOUR

T1 - Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors

AU - Van Etten, B.

AU - Eggermont, A. M.M.

AU - Ambagtsheer, G.

AU - Van Tiel, S. T.

AU - Ten Hagen, T. L.M.

PY - 2004/10/18

Y1 - 2004/10/18

N2 - Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP, A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings.

AB - Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP, A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings.

KW - Adenovirus

KW - Antibodies

KW - Gene therapy

KW - Liver perfusion

UR - https://www.scopus.com/pages/publications/7944232881

U2 - 10.1038/sj.bjc.6602151

DO - 10.1038/sj.bjc.6602151

M3 - Article

C2 - 15480435

AN - SCOPUS:7944232881

SN - 0007-0920

VL - 91

SP - 1610

EP - 1613

JO - British journal of cancer

JF - British journal of cancer

IS - 8

ER -

Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors

Abstract

Keywords

Access to Document

Fingerprint

Cite this