In-depth Characterization of Vaccine Breakthrough Infections with SARS-CoV-2 among Health Care Workers in a Dutch Academic Medical Center

Lidewij W. Rümke; Femke C. Groenveld; Yvonne M.G. Van Os; Patrique Praest; Anniek A.N. Tanja; Dorien T.C.M. De Jong; Jori Symons; Rob Schuurman; Tessa Reinders; L. Marije Hofstra; Stefan Nierkens; Steven F.T. Thijsen; Michiel Heron; Robert Jan Lebbink; Jeffrey M. Beekman; Monique Nijhuis; Annemarie M.J. Wensing

doi:10.1093/ofid/ofab553

In-depth Characterization of Vaccine Breakthrough Infections with SARS-CoV-2 among Health Care Workers in a Dutch Academic Medical Center

Lidewij W. Rümke
, Femke C. Groenveld
, Yvonne M.G. Van Os
, Patrique Praest
, Anniek A.N. Tanja
, Dorien T.C.M. De Jong
, Jori Symons
, Rob Schuurman
, Tessa Reinders
, L. Marije Hofstra
, Stefan Nierkens
, Steven F.T. Thijsen
, Michiel Heron
, Robert Jan Lebbink
, Jeffrey M. Beekman
, Monique Nijhuis
, Annemarie M.J. Wensing

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination.

Original language	English
Article number	ofab553
Pages (from-to)	ofab553
Journal	Open Forum Infectious Diseases
Volume	9
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofab553
Publication status	Published - 1 Jan 2022
Externally published	Yes

Keywords

COVID-19
SARS-CoV-2
immunity
postvaccination infection
vaccine breakthrough

Access to Document

10.1093/ofid/ofab553

Cite this

Rümke, L. W., Groenveld, F. C., Van Os, Y. M. G., Praest, P., Tanja, A. A. N., De Jong, D. T. C. M., Symons, J., Schuurman, R., Reinders, T., Hofstra, L. M., Nierkens, S., Thijsen, S. F. T., Heron, M., Lebbink, R. J., Beekman, J. M., Nijhuis, M., & Wensing, A. M. J. (2022). In-depth Characterization of Vaccine Breakthrough Infections with SARS-CoV-2 among Health Care Workers in a Dutch Academic Medical Center. Open Forum Infectious Diseases, 9(1), ofab553. Article ofab553. https://doi.org/10.1093/ofid/ofab553

@article{6f06d11c543c4555ab2c09b0c712b083,

title = "In-depth Characterization of Vaccine Breakthrough Infections with SARS-CoV-2 among Health Care Workers in a Dutch Academic Medical Center",

abstract = "Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination.",

keywords = "COVID-19, SARS-CoV-2, immunity, postvaccination infection, vaccine breakthrough",

author = "R{\"u}mke, \{Lidewij W.\} and Groenveld, \{Femke C.\} and \{Van Os\}, \{Yvonne M.G.\} and Patrique Praest and Tanja, \{Anniek A.N.\} and \{De Jong\}, \{Dorien T.C.M.\} and Jori Symons and Rob Schuurman and Tessa Reinders and Hofstra, \{L. Marije\} and Stefan Nierkens and Thijsen, \{Steven F.T.\} and Michiel Heron and Lebbink, \{Robert Jan\} and Beekman, \{Jeffrey M.\} and Monique Nijhuis and Wensing, \{Annemarie M.J.\}",

note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2022",

month = jan,

day = "1",

doi = "10.1093/ofid/ofab553",

language = "English",

volume = "9",

pages = "ofab553",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "1",

}

Rümke, LW, Groenveld, FC, Van Os, YMG, Praest, P, Tanja, AAN, De Jong, DTCM, Symons, J, Schuurman, R, Reinders, T, Hofstra, LM, Nierkens, S, Thijsen, SFT, Heron, M, Lebbink, RJ, Beekman, JM, Nijhuis, M & Wensing, AMJ 2022, 'In-depth Characterization of Vaccine Breakthrough Infections with SARS-CoV-2 among Health Care Workers in a Dutch Academic Medical Center', Open Forum Infectious Diseases, vol. 9, no. 1, ofab553, pp. ofab553. https://doi.org/10.1093/ofid/ofab553

TY - JOUR

T1 - In-depth Characterization of Vaccine Breakthrough Infections with SARS-CoV-2 among Health Care Workers in a Dutch Academic Medical Center

AU - Rümke, Lidewij W.

AU - Groenveld, Femke C.

AU - Van Os, Yvonne M.G.

AU - Praest, Patrique

AU - Tanja, Anniek A.N.

AU - De Jong, Dorien T.C.M.

AU - Symons, Jori

AU - Schuurman, Rob

AU - Reinders, Tessa

AU - Hofstra, L. Marije

AU - Nierkens, Stefan

AU - Thijsen, Steven F.T.

AU - Heron, Michiel

AU - Lebbink, Robert Jan

AU - Beekman, Jeffrey M.

AU - Nijhuis, Monique

AU - Wensing, Annemarie M.J.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination.

AB - Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination.

KW - COVID-19

KW - SARS-CoV-2

KW - immunity

KW - postvaccination infection

KW - vaccine breakthrough

UR - https://www.scopus.com/pages/publications/85124888901

U2 - 10.1093/ofid/ofab553

DO - 10.1093/ofid/ofab553

M3 - Article

C2 - 34988250

AN - SCOPUS:85124888901

SN - 2328-8957

VL - 9

SP - ofab553

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 1

M1 - ofab553

ER -

In-depth Characterization of Vaccine Breakthrough Infections with SARS-CoV-2 among Health Care Workers in a Dutch Academic Medical Center

Abstract

Keywords

Access to Document

Fingerprint

Cite this