Incidence and survival of paediatric renal tumours in the Netherlands between 1990 and 2014

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Abstract

Background: This population-based study is the first to provide a detailed analysis of trends in incidence and survival of children and adolescents diagnosed with renal malignancies in the Netherlands. Methods: Data on all renal malignancies diagnosed in paediatric patients (0–18 years) between 1990 and 2014 [N = 648, 92% Wilms tumour (WT)] were extracted from the Netherlands Cancer Registry. Five-year overall survival (OS) was estimated using the actuarial method. Time trends in incidence were assessed by calculating average annual percentage change. A parametric survival model was used to compare the multivariable-adjusted risk of dying from WT between two diagnostic periods. Results: The incidence was 8 per million person-years and was constant over time (average annual percentage change -0.8%, p = 0.29). Patients with WT had a favourable outcome in both time periods; 5-year OS was 88% in 1990–2001 and 91% in 2002–2014. Multivariable analysis showed that the risk of dying from WT was not significantly decreased in the latest period (hazard ratio, 95% CI: 0.7, 0.4–1.3). Five-year OS decreased with increasing disease stage, ranging from 95 to 100% for stage I-II and about 80% for stage III–IV to 74% for bilateral disease. Five-year OS were 81% for renal cell carcinoma, 77% for clear cell sarcoma of the kidney and 20% for malignant rhabdoid tumour of the kidney. Conclusions: Incidence of paediatric renal malignancies in the Netherlands has been stable since the 1990s. Five-year OS of WT reached 91% and was similar to findings for other developed countries. Contrary to the excellent outcome for WT, the outcome of malignant rhabdoid tumour of the kidney remained inferior.

Original languageEnglish
Pages (from-to)282-290
Number of pages9
JournalEuropean Journal of Cancer
Volume175
DOIs
Publication statusPublished - Nov 2022

Keywords

  • Cancer epidemiology
  • Incidence
  • Paediatric oncology
  • Renal tumours
  • Survival
  • Trends
  • Wilms tumour
  • Humans
  • Infant
  • Rhabdoid Tumor
  • Kidney Neoplasms/pathology
  • Adolescent
  • Wilms Tumor
  • Netherlands/epidemiology
  • Child
  • Kidney/pathology

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