TY - JOUR
T1 - Increased risk of respiratory tract infections in children with Down syndrome
T2 - The consequence of an altered immune system
AU - Bloemers, Beatrijs L.P.
AU - Broers, Chantal J.M.
AU - Bont, Louis
AU - Weijerman, Michel E.
AU - Gemke, Reinoud J.B.J.
AU - van Furth, A. Marceline
PY - 2010/10
Y1 - 2010/10
N2 - Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.
AB - Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.
KW - Adaptive immunity
KW - Down syndrome
KW - Immunology
KW - Innate immunity
KW - Respiratory tract infections
UR - http://www.scopus.com/inward/record.url?scp=77957749242&partnerID=8YFLogxK
U2 - 10.1016/j.micinf.2010.05.007
DO - 10.1016/j.micinf.2010.05.007
M3 - Short survey
C2 - 20685340
AN - SCOPUS:77957749242
SN - 1286-4579
VL - 12
SP - 799
EP - 808
JO - Microbes and Infection
JF - Microbes and Infection
IS - 11
ER -