Increased risk of respiratory tract infections in children with Down syndrome: The consequence of an altered immune system

Beatrijs L.P. Bloemers, Chantal J.M. Broers, Louis Bont, Michel E. Weijerman, Reinoud J.B.J. Gemke, A. Marceline van Furth

Research output: Contribution to journalShort surveypeer-review

86 Citations (Scopus)

Abstract

Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.

Original languageEnglish
Pages (from-to)799-808
Number of pages10
JournalMicrobes and Infection
Volume12
Issue number11
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

Keywords

  • Adaptive immunity
  • Down syndrome
  • Immunology
  • Innate immunity
  • Respiratory tract infections

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