Increased risk of respiratory tract infections in children with Down syndrome: The consequence of an altered immune system

Beatrijs L.P. Bloemers; Chantal J.M. Broers; Louis Bont; Michel E. Weijerman; Reinoud J.B.J. Gemke; A. Marceline van Furth

doi:10.1016/j.micinf.2010.05.007

Increased risk of respiratory tract infections in children with Down syndrome: The consequence of an altered immune system

Beatrijs L.P. Bloemers
, Chantal J.M. Broers
, Louis Bont
, Michel E. Weijerman
, Reinoud J.B.J. Gemke
, A. Marceline van Furth

Research output: Contribution to journal › Short survey › peer-review

95 Citations (Scopus)

Abstract

Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.

Original language	English
Pages (from-to)	799-808
Number of pages	10
Journal	Microbes and Infection
Volume	12
Issue number	11
DOIs	https://doi.org/10.1016/j.micinf.2010.05.007
Publication status	Published - Oct 2010
Externally published	Yes

Keywords

Adaptive immunity
Down syndrome
Immunology
Innate immunity
Respiratory tract infections

Access to Document

10.1016/j.micinf.2010.05.007

Cite this

@article{c351510cc8d5471dbd0fe79db8c01a92,

title = "Increased risk of respiratory tract infections in children with Down syndrome: The consequence of an altered immune system",

abstract = "Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.",

keywords = "Adaptive immunity, Down syndrome, Immunology, Innate immunity, Respiratory tract infections",

author = "Bloemers, \{Beatrijs L.P.\} and Broers, \{Chantal J.M.\} and Louis Bont and Weijerman, \{Michel E.\} and Gemke, \{Reinoud J.B.J.\} and \{van Furth\}, \{A. Marceline\}",

year = "2010",

month = oct,

doi = "10.1016/j.micinf.2010.05.007",

language = "English",

volume = "12",

pages = "799--808",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson s.r.l.",

number = "11",

}

TY - JOUR

T1 - Increased risk of respiratory tract infections in children with Down syndrome

T2 - The consequence of an altered immune system

AU - Bloemers, Beatrijs L.P.

AU - Broers, Chantal J.M.

AU - Bont, Louis

AU - Weijerman, Michel E.

AU - Gemke, Reinoud J.B.J.

AU - van Furth, A. Marceline

PY - 2010/10

Y1 - 2010/10

N2 - Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.

AB - Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.

KW - Adaptive immunity

KW - Down syndrome

KW - Immunology

KW - Innate immunity

KW - Respiratory tract infections

UR - https://www.scopus.com/pages/publications/77957749242

U2 - 10.1016/j.micinf.2010.05.007

DO - 10.1016/j.micinf.2010.05.007

M3 - Short survey

C2 - 20685340

AN - SCOPUS:77957749242

SN - 1286-4579

VL - 12

SP - 799

EP - 808

JO - Microbes and Infection

JF - Microbes and Infection

IS - 11

ER -

Increased risk of respiratory tract infections in children with Down syndrome: The consequence of an altered immune system

Abstract

Keywords

Access to Document

Fingerprint

Cite this