Influence of tumor site and histology on long-term survival in 193 children with extracranial germ cell tumors

Antoine De Backer, C. C. Madern, R. Pieters, P. Haentjens, F. C.A.J. Hakvoort-Cammel, J. W. Oosterhuis, F. W.J. Hazebroek

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53 Citations (Scopus)

Abstract

Aims: Although germ cell tumors (GCT) supposedly share the same cell type of origin, their clinical course differs considerably depending on tumor site and histology. The aim of this work was to study long-term survival stratified for tumor site and tumor histology. Materials and Methods: The medical records of 193 consecutive infants and children with extracranial GCT were studied. The GCT arose in the following anatomical sites: sacrococcygeal (n = 70), ovary (n = 66), testis (n = 20), retroperitoneum (n = 12), neck (n = 8), mediastinum (n = 7), and miscellaneous (n = 10). Histological analysis revealed 152 teratomas (mature: 115, immature: 37), 27 yolk sac tumors, 8 mixed tumors, 2 dysgerminomas, 2 gonadoblastomas, 1 choriocarcinoma and 1 embryonal carcinoma.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalEuropean Journal of Pediatric Surgery
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2008
Externally publishedYes

Keywords

  • Childhood cancer
  • Germ cell tumor
  • Survival
  • Teratoma

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