Influence of tumor site and histology on long-term survival in 193 children with extracranial germ cell tumors

Antoine De Backer; C. C. Madern; R. Pieters; P. Haentjens; F. C.A.J. Hakvoort-Cammel; J. W. Oosterhuis; F. W.J. Hazebroek

doi:10.1055/s-2007-989399

Influence of tumor site and histology on long-term survival in 193 children with extracranial germ cell tumors

Antoine De Backer
, C. C. Madern
, R. Pieters
, P. Haentjens
, F. C.A.J. Hakvoort-Cammel
, J. W. Oosterhuis
, F. W.J. Hazebroek

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Aims: Although germ cell tumors (GCT) supposedly share the same cell type of origin, their clinical course differs considerably depending on tumor site and histology. The aim of this work was to study long-term survival stratified for tumor site and tumor histology. Materials and Methods: The medical records of 193 consecutive infants and children with extracranial GCT were studied. The GCT arose in the following anatomical sites: sacrococcygeal (n = 70), ovary (n = 66), testis (n = 20), retroperitoneum (n = 12), neck (n = 8), mediastinum (n = 7), and miscellaneous (n = 10). Histological analysis revealed 152 teratomas (mature: 115, immature: 37), 27 yolk sac tumors, 8 mixed tumors, 2 dysgerminomas, 2 gonadoblastomas, 1 choriocarcinoma and 1 embryonal carcinoma.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	European Journal of Pediatric Surgery
Volume	18
Issue number	1
DOIs	https://doi.org/10.1055/s-2007-989399
Publication status	Published - Feb 2008
Externally published	Yes

Keywords

Childhood cancer
Germ cell tumor
Survival
Teratoma

Access to Document

10.1055/s-2007-989399

Cite this

@article{39a6802748a24ab1987832aacb108ead,

title = "Influence of tumor site and histology on long-term survival in 193 children with extracranial germ cell tumors",

abstract = "Aims: Although germ cell tumors (GCT) supposedly share the same cell type of origin, their clinical course differs considerably depending on tumor site and histology. The aim of this work was to study long-term survival stratified for tumor site and tumor histology. Materials and Methods: The medical records of 193 consecutive infants and children with extracranial GCT were studied. The GCT arose in the following anatomical sites: sacrococcygeal (n = 70), ovary (n = 66), testis (n = 20), retroperitoneum (n = 12), neck (n = 8), mediastinum (n = 7), and miscellaneous (n = 10). Histological analysis revealed 152 teratomas (mature: 115, immature: 37), 27 yolk sac tumors, 8 mixed tumors, 2 dysgerminomas, 2 gonadoblastomas, 1 choriocarcinoma and 1 embryonal carcinoma.",

keywords = "Childhood cancer, Germ cell tumor, Survival, Teratoma",

author = "\{De Backer\}, Antoine and Madern, \{C. C.\} and R. Pieters and P. Haentjens and Hakvoort-Cammel, \{F. C.A.J.\} and Oosterhuis, \{J. W.\} and Hazebroek, \{F. W.J.\}",

year = "2008",

month = feb,

doi = "10.1055/s-2007-989399",

language = "English",

volume = "18",

pages = "1--6",

journal = "European Journal of Pediatric Surgery",

issn = "0939-7248",

publisher = "Georg Thieme Verlag",

number = "1",

}

TY - JOUR

T1 - Influence of tumor site and histology on long-term survival in 193 children with extracranial germ cell tumors

AU - De Backer, Antoine

AU - Madern, C. C.

AU - Pieters, R.

AU - Haentjens, P.

AU - Hakvoort-Cammel, F. C.A.J.

AU - Oosterhuis, J. W.

AU - Hazebroek, F. W.J.

PY - 2008/2

Y1 - 2008/2

N2 - Aims: Although germ cell tumors (GCT) supposedly share the same cell type of origin, their clinical course differs considerably depending on tumor site and histology. The aim of this work was to study long-term survival stratified for tumor site and tumor histology. Materials and Methods: The medical records of 193 consecutive infants and children with extracranial GCT were studied. The GCT arose in the following anatomical sites: sacrococcygeal (n = 70), ovary (n = 66), testis (n = 20), retroperitoneum (n = 12), neck (n = 8), mediastinum (n = 7), and miscellaneous (n = 10). Histological analysis revealed 152 teratomas (mature: 115, immature: 37), 27 yolk sac tumors, 8 mixed tumors, 2 dysgerminomas, 2 gonadoblastomas, 1 choriocarcinoma and 1 embryonal carcinoma.

AB - Aims: Although germ cell tumors (GCT) supposedly share the same cell type of origin, their clinical course differs considerably depending on tumor site and histology. The aim of this work was to study long-term survival stratified for tumor site and tumor histology. Materials and Methods: The medical records of 193 consecutive infants and children with extracranial GCT were studied. The GCT arose in the following anatomical sites: sacrococcygeal (n = 70), ovary (n = 66), testis (n = 20), retroperitoneum (n = 12), neck (n = 8), mediastinum (n = 7), and miscellaneous (n = 10). Histological analysis revealed 152 teratomas (mature: 115, immature: 37), 27 yolk sac tumors, 8 mixed tumors, 2 dysgerminomas, 2 gonadoblastomas, 1 choriocarcinoma and 1 embryonal carcinoma.

KW - Childhood cancer

KW - Germ cell tumor

KW - Survival

KW - Teratoma

UR - https://www.scopus.com/pages/publications/40649115684

U2 - 10.1055/s-2007-989399

DO - 10.1055/s-2007-989399

M3 - Article

C2 - 18302061

AN - SCOPUS:40649115684

SN - 0939-7248

VL - 18

SP - 1

EP - 6

JO - European Journal of Pediatric Surgery

JF - European Journal of Pediatric Surgery

IS - 1

ER -

Influence of tumor site and histology on long-term survival in 193 children with extracranial germ cell tumors

Abstract

Keywords

Access to Document

Fingerprint

Cite this