Inhibin immunoreactivity in gonadal and non-gonadal tumors

F. H. De Jong; A. J. Grootenhuis; J. Steenbergen; F. J. van Sluijs; J. A. Foekens; F. J.W. ten Kate; J. W. Oosterhuis; S. W.J. Lamberts; J. G.M. Klijn

doi:10.1016/0960-0760(90)90433-L

Inhibin immunoreactivity in gonadal and non-gonadal tumors

F. H. De Jong
, A. J. Grootenhuis
, J. Steenbergen
, F. J. van Sluijs
, J. A. Foekens
, F. J.W. ten Kate
, J. W. Oosterhuis
, S. W.J. Lamberts
, J. G.M. Klijn

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Inhibin immunoreactivity was estimated in a number of gonadal and non-gonadal tumors. Dog Sertoli cell tumors and human granulosa cell and Leydig cell tumors contained high concentrations of inhibin-like material. Levels, comparable with those in normal testes and ovaries were detected in human testicular non-seminomas and in ovarian cystadenomas, thecomas and adenofibromas. No activity was found in human testicular Sertoli/Leydig cell tumors and seminomas and in ovarian adenocarcinomas, teratomas and a dysgerminoma. Furthermore, human adrenal cortical tissue (tumor and hyperplastic adrenal) contained inhibin immunoreactivity. No activity was found in human tumors of the stomach, gut, liver, kidney, pancreas and mammary gland or in meningiomas. It is concluded that inhibin is not a good marker for specific gonadal tumors. Inhibin might have intratumor actions a growth or differentiation factor.

Original language	English
Pages (from-to)	863-866
Number of pages	4
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/0960-0760(90)90433-L
Publication status	Published - 20 Dec 1990
Externally published	Yes

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@article{ea5ad80d782448959d1b21690d7fdb43,

title = "Inhibin immunoreactivity in gonadal and non-gonadal tumors",

abstract = "Inhibin immunoreactivity was estimated in a number of gonadal and non-gonadal tumors. Dog Sertoli cell tumors and human granulosa cell and Leydig cell tumors contained high concentrations of inhibin-like material. Levels, comparable with those in normal testes and ovaries were detected in human testicular non-seminomas and in ovarian cystadenomas, thecomas and adenofibromas. No activity was found in human testicular Sertoli/Leydig cell tumors and seminomas and in ovarian adenocarcinomas, teratomas and a dysgerminoma. Furthermore, human adrenal cortical tissue (tumor and hyperplastic adrenal) contained inhibin immunoreactivity. No activity was found in human tumors of the stomach, gut, liver, kidney, pancreas and mammary gland or in meningiomas. It is concluded that inhibin is not a good marker for specific gonadal tumors. Inhibin might have intratumor actions a growth or differentiation factor.",

author = "\{De Jong\}, \{F. H.\} and Grootenhuis, \{A. J.\} and J. Steenbergen and \{van Sluijs\}, \{F. J.\} and Foekens, \{J. A.\} and \{ten Kate\}, \{F. J.W.\} and Oosterhuis, \{J. W.\} and Lamberts, \{S. W.J.\} and Klijn, \{J. G.M.\}",

year = "1990",

month = dec,

day = "20",

doi = "10.1016/0960-0760(90)90433-L",

language = "English",

volume = "37",

pages = "863--866",

journal = "Journal of Steroid Biochemistry and Molecular Biology",

issn = "0960-0760",

publisher = "Elsevier Ltd.",

number = "6",

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TY - JOUR

T1 - Inhibin immunoreactivity in gonadal and non-gonadal tumors

AU - De Jong, F. H.

AU - Grootenhuis, A. J.

AU - Steenbergen, J.

AU - van Sluijs, F. J.

AU - Foekens, J. A.

AU - ten Kate, F. J.W.

AU - Oosterhuis, J. W.

AU - Lamberts, S. W.J.

AU - Klijn, J. G.M.

PY - 1990/12/20

Y1 - 1990/12/20

N2 - Inhibin immunoreactivity was estimated in a number of gonadal and non-gonadal tumors. Dog Sertoli cell tumors and human granulosa cell and Leydig cell tumors contained high concentrations of inhibin-like material. Levels, comparable with those in normal testes and ovaries were detected in human testicular non-seminomas and in ovarian cystadenomas, thecomas and adenofibromas. No activity was found in human testicular Sertoli/Leydig cell tumors and seminomas and in ovarian adenocarcinomas, teratomas and a dysgerminoma. Furthermore, human adrenal cortical tissue (tumor and hyperplastic adrenal) contained inhibin immunoreactivity. No activity was found in human tumors of the stomach, gut, liver, kidney, pancreas and mammary gland or in meningiomas. It is concluded that inhibin is not a good marker for specific gonadal tumors. Inhibin might have intratumor actions a growth or differentiation factor.

AB - Inhibin immunoreactivity was estimated in a number of gonadal and non-gonadal tumors. Dog Sertoli cell tumors and human granulosa cell and Leydig cell tumors contained high concentrations of inhibin-like material. Levels, comparable with those in normal testes and ovaries were detected in human testicular non-seminomas and in ovarian cystadenomas, thecomas and adenofibromas. No activity was found in human testicular Sertoli/Leydig cell tumors and seminomas and in ovarian adenocarcinomas, teratomas and a dysgerminoma. Furthermore, human adrenal cortical tissue (tumor and hyperplastic adrenal) contained inhibin immunoreactivity. No activity was found in human tumors of the stomach, gut, liver, kidney, pancreas and mammary gland or in meningiomas. It is concluded that inhibin is not a good marker for specific gonadal tumors. Inhibin might have intratumor actions a growth or differentiation factor.

UR - https://www.scopus.com/pages/publications/0025688731

U2 - 10.1016/0960-0760(90)90433-L

DO - 10.1016/0960-0760(90)90433-L

M3 - Article

C2 - 2285598

AN - SCOPUS:0025688731

SN - 0960-0760

VL - 37

SP - 863

EP - 866

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

IS - 6

ER -

Inhibin immunoreactivity in gonadal and non-gonadal tumors

Abstract

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