Abstract
Cytarabine (1000 mg/m/d intravenous for 5 d) and clofarabine (40 mg/m/d intravenous for 5 d) were given every 28 days to 9 children with relapsed acute myeloid leukemia at our institution. Among 19 courses, there were 18 infectious episodes. Median hospitalization time was 13 days (7.7 to 30.5 d) per cycle. Hepatobiliary abnormalities included alanine aminotransferase/aspartate aminotransferase elevation and hyperbilirubinemia. Four patients achieved complete remission (one after an earlier allogeneic Haematopoietic Progenitor Cell Transplant). Four patients are alive disease free. In summary, a proportion of children responded and was able to receive allogeneic Haematopoietic Progenitor Cell Transplant. Side effects were tolerable, although hospitalization time was prolonged.
| Original language | English |
|---|---|
| Pages (from-to) | e17-21 |
| Journal | Journal of pediatric hematology/oncology |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2012 |
| Externally published | Yes |
Keywords
- Adenine Nucleotides/administration & dosage
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols/therapeutic use
- Arabinonucleosides/administration & dosage
- Child
- Child, Preschool
- Clofarabine
- Cytarabine/administration & dosage
- Female
- Hematopoietic Stem Cell Transplantation
- Humans
- Infant
- Leukemia, Myeloid, Acute/drug therapy
- Male
- Recurrence
- Retrospective Studies
- Transplantation, Homologous