Insulin-like growth factor I (IGF-I) and cognitive decline in older persons

Miranda G. Dik; Saskia M.F. Pluijm; Cees Jonker; Dorly J.H. Deeg; Marie Z. Lomecky; Paul Lips

doi:10.1016/S0197-4580(02)00136-7

Insulin-like growth factor I (IGF-I) and cognitive decline in older persons

Miranda G. Dik, Saskia M.F. Pluijm, Cees Jonker, Dorly J.H. Deeg, Marie Z. Lomecky, Paul Lips

Research output: Contribution to journal › Article › peer-review

112 Citations (Scopus)

Abstract

Insulin-like growth factor I (IGF-I) deficiency may be involved in cognitive deficits seen with aging, and in neurodegenerative diseases such as Alzheimer's disease. The objective of this study was to investigate whether IGF-I is associated with cognitive performance and 3-year cognitive decline in 1318 subjects, aged 65-88 years. Cross-sectionally, IGF-I was directly related to information processing speed, memory, fluid intelligence, and Mini-Mental State Examination (MMSE) score, but these associations did not remain significant after adjustment for age and other factors. Analysis in quintiles of IGF-I revealed a threshold effect of low IGF-I on information processing speed, with lower speed in subjects in the lowest quintile of IGF-I (<9.4nmol/l)¹ versus those in the other four quintiles (fully adjusted B=-0.89; 95% CI, -1.72 to -0.05). This threshold of low IGF-I was also observed for 3-year decline in information processing speed (adjusted RR=1.78; 95% CI, 1.19-2.68). In summary, this study suggests that IGF-I levels below 9.4nmol/l are negatively associated with both the level and decline of information processing speed.

Original language	English
Pages (from-to)	573-581
Number of pages	9
Journal	Neurobiology of Aging
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/S0197-4580(02)00136-7
Publication status	Published - Jul 2003
Externally published	Yes

Keywords

Cognition
Elderly
Longitudinal studies
Serum IGF-I

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10.1016/S0197-4580(02)00136-7

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title = "Insulin-like growth factor I (IGF-I) and cognitive decline in older persons",

abstract = "Insulin-like growth factor I (IGF-I) deficiency may be involved in cognitive deficits seen with aging, and in neurodegenerative diseases such as Alzheimer's disease. The objective of this study was to investigate whether IGF-I is associated with cognitive performance and 3-year cognitive decline in 1318 subjects, aged 65-88 years. Cross-sectionally, IGF-I was directly related to information processing speed, memory, fluid intelligence, and Mini-Mental State Examination (MMSE) score, but these associations did not remain significant after adjustment for age and other factors. Analysis in quintiles of IGF-I revealed a threshold effect of low IGF-I on information processing speed, with lower speed in subjects in the lowest quintile of IGF-I (<9.4nmol/l)1 versus those in the other four quintiles (fully adjusted B=-0.89; 95% CI, -1.72 to -0.05). This threshold of low IGF-I was also observed for 3-year decline in information processing speed (adjusted RR=1.78; 95% CI, 1.19-2.68). In summary, this study suggests that IGF-I levels below 9.4nmol/l are negatively associated with both the level and decline of information processing speed.",

keywords = "Cognition, Elderly, Longitudinal studies, Serum IGF-I",

author = "Dik, {Miranda G.} and Pluijm, {Saskia M.F.} and Cees Jonker and Deeg, {Dorly J.H.} and Lomecky, {Marie Z.} and Paul Lips",

note = "Funding Information: The Longitudinal Aging Study Amsterdam (LASA) is funded by the Dutch Ministry of Health, Welfare and Sports, and the Vrije Universiteit. The study on cognitive decline is supported by grantnumber 940-90-001 of the Dutch Organization for Scientific Research (NWO-MW). The authors would like to thank the Endocrine Laboratory of the VU University Medical Center for determination of serum IGF-I. ",

year = "2003",

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doi = "10.1016/S0197-4580(02)00136-7",

language = "English",

volume = "24",

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AU - Dik, Miranda G.

AU - Pluijm, Saskia M.F.

AU - Jonker, Cees

AU - Deeg, Dorly J.H.

AU - Lomecky, Marie Z.

AU - Lips, Paul

N1 - Funding Information: The Longitudinal Aging Study Amsterdam (LASA) is funded by the Dutch Ministry of Health, Welfare and Sports, and the Vrije Universiteit. The study on cognitive decline is supported by grantnumber 940-90-001 of the Dutch Organization for Scientific Research (NWO-MW). The authors would like to thank the Endocrine Laboratory of the VU University Medical Center for determination of serum IGF-I.

PY - 2003/7

Y1 - 2003/7

N2 - Insulin-like growth factor I (IGF-I) deficiency may be involved in cognitive deficits seen with aging, and in neurodegenerative diseases such as Alzheimer's disease. The objective of this study was to investigate whether IGF-I is associated with cognitive performance and 3-year cognitive decline in 1318 subjects, aged 65-88 years. Cross-sectionally, IGF-I was directly related to information processing speed, memory, fluid intelligence, and Mini-Mental State Examination (MMSE) score, but these associations did not remain significant after adjustment for age and other factors. Analysis in quintiles of IGF-I revealed a threshold effect of low IGF-I on information processing speed, with lower speed in subjects in the lowest quintile of IGF-I (<9.4nmol/l)1 versus those in the other four quintiles (fully adjusted B=-0.89; 95% CI, -1.72 to -0.05). This threshold of low IGF-I was also observed for 3-year decline in information processing speed (adjusted RR=1.78; 95% CI, 1.19-2.68). In summary, this study suggests that IGF-I levels below 9.4nmol/l are negatively associated with both the level and decline of information processing speed.

AB - Insulin-like growth factor I (IGF-I) deficiency may be involved in cognitive deficits seen with aging, and in neurodegenerative diseases such as Alzheimer's disease. The objective of this study was to investigate whether IGF-I is associated with cognitive performance and 3-year cognitive decline in 1318 subjects, aged 65-88 years. Cross-sectionally, IGF-I was directly related to information processing speed, memory, fluid intelligence, and Mini-Mental State Examination (MMSE) score, but these associations did not remain significant after adjustment for age and other factors. Analysis in quintiles of IGF-I revealed a threshold effect of low IGF-I on information processing speed, with lower speed in subjects in the lowest quintile of IGF-I (<9.4nmol/l)1 versus those in the other four quintiles (fully adjusted B=-0.89; 95% CI, -1.72 to -0.05). This threshold of low IGF-I was also observed for 3-year decline in information processing speed (adjusted RR=1.78; 95% CI, 1.19-2.68). In summary, this study suggests that IGF-I levels below 9.4nmol/l are negatively associated with both the level and decline of information processing speed.

KW - Cognition

KW - Elderly

KW - Longitudinal studies

KW - Serum IGF-I

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JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 4

ER -

Insulin-like growth factor I (IGF-I) and cognitive decline in older persons

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Keywords

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