Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent

Keyphrases

• Primary Hepatocytes 100%
• Drug-induced Cholestasis 100%
• 3D Spheroid Culture 60%
• Repeated Exposure 40%
• Chlorpromazine 40%
• Troglitazone 40%
• Non-cytotoxic 40%
• Cell Viability 20%
• Cytotoxic Drugs 20%
• Drug Concentration 20%
• Cyclosporine 20%
• Drug-induced Liver Injury 20%
• Short-term Exposure 20%
• Cholestasis 20%
• Exposure Time 20%
• Bile Acids 20%
• Acid Mixture 20%
• Cholestatic Hepatotoxicity 20%
• Amiodarone 20%
• Hepatotoxin 20%
• Bosentan 20%
• Sandwich Culture 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Cholestasis 100%
• Chlorpromazine 66%
• Troglitazone 66%
• Cytotoxic Agent 33%
• Cell Viability 33%
• Bile Acid 33%
• Hepatotoxicity 33%
• Drug Concentration 33%
• Ciclosporin 33%
• Toxic Hepatitis 33%
• Hepatotoxin 33%
• Amiodarone 33%
• Bosentan 33%