Intestinal Regeneration: Regulation by the Microenvironment

Joris H. Hageman, Maria C. Heinz, Kai Kretzschmar, Jelte van der Vaart, Hans Clevers, Hugo J.G. Snippert

Research output: Contribution to journalReview articlepeer-review

94 Citations (Scopus)


Damage to the intestinal stem cell niche can result from mechanical stress, infections, chronic inflammation or cytotoxic therapies. Progenitor cells can compensate for insults to the stem cell population through dedifferentiation. The microenvironment modulates this regenerative response by influencing the activity of signaling pathways, including Wnt, Notch, and YAP/TAZ. For instance, mesenchymal cells and immune cells become more abundant after damage and secrete signaling molecules that promote the regenerative process. Furthermore, regeneration is influenced by the nutritional state, microbiome, and extracellular matrix. Here, we review how all these components cooperate to restore epithelial homeostasis in the intestine after injury.

Original languageEnglish
Pages (from-to)435-446
Number of pages12
JournalDevelopmental Cell
Issue number4
Publication statusPublished - 24 Aug 2020


  • cellular plasticity
  • colon
  • dedifferentiation
  • epithelial damage
  • immune cells
  • intestine
  • Lgr5
  • mesenchymal cells
  • niche
  • stem cell


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