Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

Vivian S.W. Li, Hans Clevers

Research output: Contribution to journalShort surveypeer-review

15 Citations (Scopus)

Abstract

The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.

Original languageEnglish
Pages (from-to)R110-R112
JournalCurrent Biology
Volume23
Issue number3
DOIs
Publication statusPublished - 4 Feb 2013
Externally publishedYes

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