Intravascular photoacoustic imaging of human coronary atherosclerosis

Krista Jansen, Antonius F.W. Van Der Steen, Heleen M.M. Van Beusekom, J. Wolter Oosterhuis, Gijs Van Soest

Research output: Contribution to journalArticlepeer-review

240 Citations (Scopus)


We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing different stages of disease. A 1:25mm diameter intravascular imaging catheter was built, comprising an angle-polished optical fiber adjacent to a 30 MHz ultrasound transducer. Specific photoacoustic imaging of lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230nm. Simultaneous imaging with intravascular ultrasound was performed. 2011 Optical Society of America.

Original languageEnglish
Pages (from-to)597-599
Number of pages3
JournalOptics Letters
Issue number5
Publication statusPublished - 1 Mar 2011
Externally publishedYes


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