Intravascular photoacoustic imaging of human coronary atherosclerosis

Krista Jansen; Antonius F.W. Van Der Steen; Heleen M.M. Van Beusekom; J. Wolter Oosterhuis; Gijs Van Soest

doi:10.1364/OL.36.000597

Intravascular photoacoustic imaging of human coronary atherosclerosis

Krista Jansen
, Antonius F.W. Van Der Steen
, Heleen M.M. Van Beusekom
, J. Wolter Oosterhuis
, Gijs Van Soest

Research output: Contribution to journal › Article › peer-review

265 Citations (Scopus)

Abstract

We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing different stages of disease. A 1:25mm diameter intravascular imaging catheter was built, comprising an angle-polished optical fiber adjacent to a 30 MHz ultrasound transducer. Specific photoacoustic imaging of lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230nm. Simultaneous imaging with intravascular ultrasound was performed. 2011 Optical Society of America.

Original language	English
Pages (from-to)	597-599
Number of pages	3
Journal	Optics Letters
Volume	36
Issue number	5
DOIs	https://doi.org/10.1364/OL.36.000597
Publication status	Published - 1 Mar 2011
Externally published	Yes

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author = "Krista Jansen and \{Van Der Steen\}, \{Antonius F.W.\} and \{Van Beusekom\}, \{Heleen M.M.\} and Oosterhuis, \{J. Wolter\} and \{Van Soest\}, Gijs",

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AU - Van Beusekom, Heleen M.M.

AU - Oosterhuis, J. Wolter

AU - Van Soest, Gijs

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N2 - We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing different stages of disease. A 1:25mm diameter intravascular imaging catheter was built, comprising an angle-polished optical fiber adjacent to a 30 MHz ultrasound transducer. Specific photoacoustic imaging of lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230nm. Simultaneous imaging with intravascular ultrasound was performed. 2011 Optical Society of America.

AB - We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing different stages of disease. A 1:25mm diameter intravascular imaging catheter was built, comprising an angle-polished optical fiber adjacent to a 30 MHz ultrasound transducer. Specific photoacoustic imaging of lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230nm. Simultaneous imaging with intravascular ultrasound was performed. 2011 Optical Society of America.

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Intravascular photoacoustic imaging of human coronary atherosclerosis

Abstract

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