Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group

Janna A. Hol; Marry M. van den Heuvel-Eibrink; Norbert Graf; Kathy Pritchard-Jones; Jesper Brok; Harm van Tinteren; Lisa Howell; Arnauld Verschuur; Christophe Bergeron; Leo Kager; Serena Catania; Filippo Spreafico; Annelies M.C. Mavinkurve-Groothuis

doi:10.1002/pbc.26849

Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group

Janna A. Hol, Marry M. van den Heuvel-Eibrink, Norbert Graf, Kathy Pritchard-Jones, Jesper Brok, Harm van Tinteren, Lisa Howell, Arnauld Verschuur, Christophe Bergeron, Leo Kager, Serena Catania, Filippo Spreafico, Annelies M.C. Mavinkurve-Groothuis

Group van den Heuvel

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

While irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan-containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate-risk (CR and PR) and blastemal-type histologies (PR). Two patients were alive at last follow-up showing no evidence of disease. Our results and the reviewed literature suggest some effectiveness of irinotecan in the setting of relapsed WT.

Original language	English
Article number	e26849
Journal	Pediatric Blood and Cancer
Volume	65
Issue number	2
DOIs	https://doi.org/10.1002/pbc.26849
Publication status	Published - Feb 2018

Keywords

irinotecan
pediatric solid tumors
relapsed Wilms tumor

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Hol, J. A., van den Heuvel-Eibrink, M. M., Graf, N., Pritchard-Jones, K., Brok, J., van Tinteren, H., Howell, L., Verschuur, A., Bergeron, C., Kager, L., Catania, S., Spreafico, F., & Mavinkurve-Groothuis, A. M. C. (2018). Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group. Pediatric Blood and Cancer, 65(2), Article e26849. https://doi.org/10.1002/pbc.26849

@article{2c309a43876c4399acf1e7ca5d297c0a,

title = "Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group",

abstract = "While irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan-containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate-risk (CR and PR) and blastemal-type histologies (PR). Two patients were alive at last follow-up showing no evidence of disease. Our results and the reviewed literature suggest some effectiveness of irinotecan in the setting of relapsed WT.",

keywords = "irinotecan, pediatric solid tumors, relapsed Wilms tumor",

author = "Hol, {Janna A.} and {van den Heuvel-Eibrink}, {Marry M.} and Norbert Graf and Kathy Pritchard-Jones and Jesper Brok and {van Tinteren}, Harm and Lisa Howell and Arnauld Verschuur and Christophe Bergeron and Leo Kager and Serena Catania and Filippo Spreafico and Mavinkurve-Groothuis, {Annelies M.C.}",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",

year = "2018",

month = feb,

doi = "10.1002/pbc.26849",

language = "English",

volume = "65",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

publisher = "Wiley-Liss Inc.",

number = "2",

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Hol, JA, van den Heuvel-Eibrink, MM, Graf, N, Pritchard-Jones, K, Brok, J, van Tinteren, H, Howell, L, Verschuur, A, Bergeron, C, Kager, L, Catania, S, Spreafico, F & Mavinkurve-Groothuis, AMC 2018, 'Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group', Pediatric Blood and Cancer, vol. 65, no. 2, e26849. https://doi.org/10.1002/pbc.26849

TY - JOUR

T1 - Irinotecan for relapsed Wilms tumor in pediatric patients

T2 - SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group

AU - Hol, Janna A.

AU - van den Heuvel-Eibrink, Marry M.

AU - Graf, Norbert

AU - Pritchard-Jones, Kathy

AU - Brok, Jesper

AU - van Tinteren, Harm

AU - Howell, Lisa

AU - Verschuur, Arnauld

AU - Bergeron, Christophe

AU - Kager, Leo

AU - Catania, Serena

AU - Spreafico, Filippo

AU - Mavinkurve-Groothuis, Annelies M.C.

PY - 2018/2

Y1 - 2018/2

N2 - While irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan-containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate-risk (CR and PR) and blastemal-type histologies (PR). Two patients were alive at last follow-up showing no evidence of disease. Our results and the reviewed literature suggest some effectiveness of irinotecan in the setting of relapsed WT.

AB - While irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan-containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate-risk (CR and PR) and blastemal-type histologies (PR). Two patients were alive at last follow-up showing no evidence of disease. Our results and the reviewed literature suggest some effectiveness of irinotecan in the setting of relapsed WT.

KW - irinotecan

KW - pediatric solid tumors

KW - relapsed Wilms tumor

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U2 - 10.1002/pbc.26849

DO - 10.1002/pbc.26849

M3 - Article

C2 - 29077255

AN - SCOPUS:85038590813

SN - 1545-5009

VL - 65

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 2

M1 - e26849

ER -

Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group

Abstract

Keywords

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