TY - JOUR
T1 - Isolated Hepatic Perfusion for the Treatment of Liver Tumors
T2 - Sunset or Sunrise?
AU - Verhoef, Cornelis
AU - de Wilt, Johannes H.W.
AU - ten Hagen, Timo L.M.
AU - Eggermont, Alexander M.M.
PY - 2008/10
Y1 - 2008/10
N2 - Experience with isolated hepatic perfusion (IHP) is limited to a few centers in the world because of the technical difficulties, surgery-related morbidity, and unproved efficacy in randomized trials. Experimental animal IHP models have led to exploring new ways of improving efficacy, reducing technical difficulties, and minimizing regional and systemic toxicity. Future research should be directed to the identification of suitable biologic or chemotherapeutic agents, defining clinical indications, and development of technical modifications to make it more generally applicable and even repeatable.
AB - Experience with isolated hepatic perfusion (IHP) is limited to a few centers in the world because of the technical difficulties, surgery-related morbidity, and unproved efficacy in randomized trials. Experimental animal IHP models have led to exploring new ways of improving efficacy, reducing technical difficulties, and minimizing regional and systemic toxicity. Future research should be directed to the identification of suitable biologic or chemotherapeutic agents, defining clinical indications, and development of technical modifications to make it more generally applicable and even repeatable.
UR - http://www.scopus.com/inward/record.url?scp=49649093044&partnerID=8YFLogxK
U2 - 10.1016/j.soc.2008.04.007
DO - 10.1016/j.soc.2008.04.007
M3 - Review article
C2 - 18722924
AN - SCOPUS:49649093044
SN - 1055-3207
VL - 17
SP - 877
EP - 894
JO - Surgical Oncology Clinics of North America
JF - Surgical Oncology Clinics of North America
IS - 4
ER -