Isolated Hepatic Perfusion for the Treatment of Liver Tumors: Sunset or Sunrise?

Cornelis Verhoef; Johannes H.W. de Wilt; Timo L.M. ten Hagen; Alexander M.M. Eggermont

doi:10.1016/j.soc.2008.04.007

Isolated Hepatic Perfusion for the Treatment of Liver Tumors: Sunset or Sunrise?

Cornelis Verhoef
, Johannes H.W. de Wilt
, Timo L.M. ten Hagen
, Alexander M.M. Eggermont

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Experience with isolated hepatic perfusion (IHP) is limited to a few centers in the world because of the technical difficulties, surgery-related morbidity, and unproved efficacy in randomized trials. Experimental animal IHP models have led to exploring new ways of improving efficacy, reducing technical difficulties, and minimizing regional and systemic toxicity. Future research should be directed to the identification of suitable biologic or chemotherapeutic agents, defining clinical indications, and development of technical modifications to make it more generally applicable and even repeatable.

Original language	English
Pages (from-to)	877-894
Number of pages	18
Journal	Surgical Oncology Clinics of North America
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.soc.2008.04.007
Publication status	Published - Oct 2008
Externally published	Yes

Access to Document

10.1016/j.soc.2008.04.007

Cite this

@article{358b755bdb92405f9686f6cf7917d212,

title = "Isolated Hepatic Perfusion for the Treatment of Liver Tumors: Sunset or Sunrise?",

abstract = "Experience with isolated hepatic perfusion (IHP) is limited to a few centers in the world because of the technical difficulties, surgery-related morbidity, and unproved efficacy in randomized trials. Experimental animal IHP models have led to exploring new ways of improving efficacy, reducing technical difficulties, and minimizing regional and systemic toxicity. Future research should be directed to the identification of suitable biologic or chemotherapeutic agents, defining clinical indications, and development of technical modifications to make it more generally applicable and even repeatable.",

author = "Cornelis Verhoef and \{de Wilt\}, \{Johannes H.W.\} and \{ten Hagen\}, \{Timo L.M.\} and Eggermont, \{Alexander M.M.\}",

year = "2008",

month = oct,

doi = "10.1016/j.soc.2008.04.007",

language = "English",

volume = "17",

pages = "877--894",

journal = "Surgical Oncology Clinics of North America",

issn = "1055-3207",

publisher = "W.B. Saunders",

number = "4",

}

TY - JOUR

T1 - Isolated Hepatic Perfusion for the Treatment of Liver Tumors

T2 - Sunset or Sunrise?

AU - Verhoef, Cornelis

AU - de Wilt, Johannes H.W.

AU - ten Hagen, Timo L.M.

AU - Eggermont, Alexander M.M.

PY - 2008/10

Y1 - 2008/10

N2 - Experience with isolated hepatic perfusion (IHP) is limited to a few centers in the world because of the technical difficulties, surgery-related morbidity, and unproved efficacy in randomized trials. Experimental animal IHP models have led to exploring new ways of improving efficacy, reducing technical difficulties, and minimizing regional and systemic toxicity. Future research should be directed to the identification of suitable biologic or chemotherapeutic agents, defining clinical indications, and development of technical modifications to make it more generally applicable and even repeatable.

AB - Experience with isolated hepatic perfusion (IHP) is limited to a few centers in the world because of the technical difficulties, surgery-related morbidity, and unproved efficacy in randomized trials. Experimental animal IHP models have led to exploring new ways of improving efficacy, reducing technical difficulties, and minimizing regional and systemic toxicity. Future research should be directed to the identification of suitable biologic or chemotherapeutic agents, defining clinical indications, and development of technical modifications to make it more generally applicable and even repeatable.

UR - https://www.scopus.com/pages/publications/49649093044

U2 - 10.1016/j.soc.2008.04.007

DO - 10.1016/j.soc.2008.04.007

M3 - Review article

C2 - 18722924

AN - SCOPUS:49649093044

SN - 1055-3207

VL - 17

SP - 877

EP - 894

JO - Surgical Oncology Clinics of North America

JF - Surgical Oncology Clinics of North America

IS - 4

ER -

Isolated Hepatic Perfusion for the Treatment of Liver Tumors: Sunset or Sunrise?

Abstract

Access to Document

Fingerprint

Cite this