Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor

Anne Marie Vos, J. Wolter Oosterhuis, Bauke de Jong, Sérgio M.M.J. Castedo, Harry Hollema, Janneke Buist, Jan G. Aalders

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalCancer Genetics and Cytogenetics
Issue number2
Publication statusPublished - Feb 1990
Externally publishedYes


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