Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor

Anne Marie Vos; J. Wolter Oosterhuis; Bauke de Jong; Sérgio M.M.J. Castedo; Harry Hollema; Janneke Buist; Jan G. Aalders

doi:10.1016/0165-4608(90)90051-B

Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor

Anne Marie Vos, J. Wolter Oosterhuis, Bauke de Jong, Sérgio M.M.J. Castedo, Harry Hollema, Janneke Buist, Jan G. Aalders

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.

Original language	English
Pages (from-to)	223-228
Number of pages	6
Journal	Cancer Genetics and Cytogenetics
Volume	44
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(90)90051-B
Publication status	Published - Feb 1990
Externally published	Yes

Access to Document

10.1016/0165-4608(90)90051-B

Cite this

@article{ca327da874ba432c8eaf45afc89ad192,

title = "Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor",

abstract = "We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.",

author = "Vos, {Anne Marie} and Oosterhuis, {J. Wolter} and {de Jong}, Bauke and Castedo, {S{\'e}rgio M.M.J.} and Harry Hollema and Janneke Buist and Aalders, {Jan G.}",

year = "1990",

month = feb,

doi = "10.1016/0165-4608(90)90051-B",

language = "English",

volume = "44",

pages = "223--228",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor

AU - Vos, Anne Marie

AU - Oosterhuis, J. Wolter

AU - de Jong, Bauke

AU - Castedo, Sérgio M.M.J.

AU - Hollema, Harry

AU - Buist, Janneke

AU - Aalders, Jan G.

PY - 1990/2

Y1 - 1990/2

N2 - We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.

AB - We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.

UR - http://www.scopus.com/inward/record.url?scp=0025124450&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(90)90051-B

DO - 10.1016/0165-4608(90)90051-B

M3 - Article

C2 - 2297683

AN - SCOPUS:0025124450

SN - 0165-4608

VL - 44

SP - 223

EP - 228

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor

Abstract

Access to Document

Fingerprint

Cite this