Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor

Anne Marie Vos; J. Wolter Oosterhuis; Bauke de Jong; Sérgio M.M.J. Castedo; Harry Hollema; Janneke Buist; Jan G. Aalders

doi:10.1016/0165-4608(90)90051-B

Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor

Anne Marie Vos
, J. Wolter Oosterhuis
, Bauke de Jong
, Sérgio M.M.J. Castedo
, Harry Hollema
, Janneke Buist
, Jan G. Aalders

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.

Original language	English
Pages (from-to)	223-228
Number of pages	6
Journal	Cancer Genetics and Cytogenetics
Volume	44
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(90)90051-B
Publication status	Published - Feb 1990
Externally published	Yes

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title = "Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor",

abstract = "We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.",

author = "Vos, \{Anne Marie\} and Oosterhuis, \{J. Wolter\} and \{de Jong\}, Bauke and Castedo, \{S{\'e}rgio M.M.J.\} and Harry Hollema and Janneke Buist and Aalders, \{Jan G.\}",

year = "1990",

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doi = "10.1016/0165-4608(90)90051-B",

language = "English",

volume = "44",

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journal = "Cancer Genetics and Cytogenetics",

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T1 - Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor

AU - Vos, Anne Marie

AU - Oosterhuis, J. Wolter

AU - de Jong, Bauke

AU - Castedo, Sérgio M.M.J.

AU - Hollema, Harry

AU - Buist, Janneke

AU - Aalders, Jan G.

PY - 1990/2

Y1 - 1990/2

N2 - We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.

AB - We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.

UR - https://www.scopus.com/pages/publications/0025124450

U2 - 10.1016/0165-4608(90)90051-B

DO - 10.1016/0165-4608(90)90051-B

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AN - SCOPUS:0025124450

SN - 0165-4608

VL - 44

SP - 223

EP - 228

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor

Abstract

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