TY - JOUR
T1 - Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort
AU - LATER Study Group
AU - Kilsdonk, Ellen
AU - van Dulmen-den Broeder, Eline
AU - van Leeuwen, Flora E
AU - van den Heuvel-Eibrink, Marry M
AU - Loonen, Jacqueline J
AU - van der Pal, Helena J
AU - Bresters, Dorine
AU - Versluys, A B
AU - Pieters, Rob
AU - Hauptmann, Michael
AU - Jaspers, Monique W M
AU - Neggers, Sebastian J C
AU - Raphael, Martine F
AU - Tissing, Wim J E
AU - Kremer, Leontine C M
AU - Ronckers, Cécile M
PY - 2022/5
Y1 - 2022/5
N2 - This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later (p-trend <0.001).
AB - This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later (p-trend <0.001).
KW - Bone Neoplasms/mortality
KW - Cancer Survivors
KW - Cause of Death
KW - Child
KW - Cohort Studies
KW - Humans
KW - Neoplasms/diagnosis
KW - Netherlands/epidemiology
U2 - 10.1080/07357907.2022.2034841
DO - 10.1080/07357907.2022.2034841
M3 - Article
C2 - 35175864
SN - 0735-7907
VL - 40
SP - 413
EP - 424
JO - Cancer investigation
JF - Cancer investigation
IS - 5
ER -