Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin

Hugo J. Snippert; Andrea Haegebarth; Maria Kasper; Viljar Jaks; Johan H. Van Es; Nick Barker; Marc Van De Wetering; Maaike Van Den Born; Harry Begthel; Robert G. Vries; Daniel E. Stange; Rune Toftgård; Hans Clevers

doi:10.1126/science.1184733

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin

Hugo J. Snippert
, Andrea Haegebarth
, Maria Kasper
, Viljar Jaks
, Johan H. Van Es
, Nick Barker
, Marc Van De Wetering
, Maaike Van Den Born
, Harry Begthel
, Robert G. Vries
, Daniel E. Stange
, Rune Toftgård
, Hans Clevers

Research output: Contribution to journal › Article › peer-review

673 Citations (Scopus)

Abstract

Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicuLar epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicuLar epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.

Original language	English
Pages (from-to)	1385-1389
Number of pages	5
Journal	Science
Volume	327
Issue number	5971
DOIs	https://doi.org/10.1126/science.1184733
Publication status	Published - 12 Mar 2010
Externally published	Yes

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@article{de9e38133263488d94380a1fdf836ea5,

title = "Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin",

abstract = "Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicuLar epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicuLar epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.",

author = "Snippert, \{Hugo J.\} and Andrea Haegebarth and Maria Kasper and Viljar Jaks and \{Van Es\}, \{Johan H.\} and Nick Barker and \{Van De Wetering\}, Marc and \{Van Den Born\}, Maaike and Harry Begthel and Vries, \{Robert G.\} and Stange, \{Daniel E.\} and Rune Toftg{\aa}rd and Hans Clevers",

year = "2010",

month = mar,

day = "12",

doi = "10.1126/science.1184733",

language = "English",

volume = "327",

pages = "1385--1389",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5971",

}

TY - JOUR

T1 - Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin

AU - Snippert, Hugo J.

AU - Haegebarth, Andrea

AU - Kasper, Maria

AU - Jaks, Viljar

AU - Van Es, Johan H.

AU - Barker, Nick

AU - Van De Wetering, Marc

AU - Van Den Born, Maaike

AU - Begthel, Harry

AU - Vries, Robert G.

AU - Stange, Daniel E.

AU - Toftgård, Rune

AU - Clevers, Hans

PY - 2010/3/12

Y1 - 2010/3/12

N2 - Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicuLar epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicuLar epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.

AB - Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicuLar epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicuLar epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.

UR - https://www.scopus.com/pages/publications/77949360959

U2 - 10.1126/science.1184733

DO - 10.1126/science.1184733

M3 - Article

C2 - 20223988

AN - SCOPUS:77949360959

SN - 0036-8075

VL - 327

SP - 1385

EP - 1389

JO - Science

JF - Science

IS - 5971

ER -

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin

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