Live and let die in the intestinal epithelium

Elena Sancho, Eduard Batlle, Hans Clevers

Research output: Contribution to journalReview articlepeer-review

183 Citations (Scopus)

Abstract

The intestinal epithelium is a relatively simple developmental system and a prime example of tissue renewal from a source of multipotent stem cells. Throughout adulthood, intestinal epithelial proliferation, cell-fate specification and differentiation are coupled to migration in discrete units known as crypts of Lieberkühn. Physically guided by Eph receptors and their ligands, the ephrins, stem cell progeny transit through the proliferation/differentiation switch, and Notch diversifies their subsequent fates. Wnt signalling appears to control most of these events.

Original languageEnglish
Pages (from-to)763-770
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume15
Issue number6
DOIs
Publication statusPublished - Dec 2003
Externally publishedYes

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