Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

C. Troelstra; R. M. Landsvater; J. Wiegant; M. van der Ploeg; G. Viel; C. H.C.M. Buys; J. H.J. Hoeijmakers

doi:10.1016/0888-7543(92)90304-B

Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

C. Troelstra, R. M. Landsvater, J. Wiegant, M. van der Ploeg, G. Viel, C. H.C.M. Buys, J. H.J. Hoeijmakers

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster ovary cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse × human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.

Original language	English
Pages (from-to)	745-749
Number of pages	5
Journal	Genomics
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/0888-7543(92)90304-B
Publication status	Published - Apr 1992
Externally published	Yes

Access to Document

10.1016/0888-7543(92)90304-B

Cite this

@article{bdb3126741b943419323091807abc338,

title = "Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21",

abstract = "We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster ovary cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse × human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.",

author = "C. Troelstra and Landsvater, {R. M.} and J. Wiegant and {van der Ploeg}, M. and G. Viel and Buys, {C. H.C.M.} and Hoeijmakers, {J. H.J.}",

note = "Funding Information: We are grateful to Dr. D. Bootsma for helpful suggestions and critical reading of the manuscript. We thank M. Kuit for photography. This study was supported in part (R.M.L., G.V., and C.H.C.M.B.) the Dutch Prevention Fund.",

year = "1992",

month = apr,

doi = "10.1016/0888-7543(92)90304-B",

language = "English",

volume = "12",

pages = "745--749",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "4",

}

TY - JOUR

T1 - Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

AU - Troelstra, C.

AU - Landsvater, R. M.

AU - Wiegant, J.

AU - van der Ploeg, M.

AU - Viel, G.

AU - Buys, C. H.C.M.

AU - Hoeijmakers, J. H.J.

N1 - Funding Information: We are grateful to Dr. D. Bootsma for helpful suggestions and critical reading of the manuscript. We thank M. Kuit for photography. This study was supported in part (R.M.L., G.V., and C.H.C.M.B.) the Dutch Prevention Fund.

PY - 1992/4

Y1 - 1992/4

N2 - We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster ovary cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse × human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.

AB - We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster ovary cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse × human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.

UR - http://www.scopus.com/inward/record.url?scp=0026604950&partnerID=8YFLogxK

U2 - 10.1016/0888-7543(92)90304-B

DO - 10.1016/0888-7543(92)90304-B

M3 - Article

C2 - 1349298

AN - SCOPUS:0026604950

SN - 0888-7543

VL - 12

SP - 745

EP - 749

JO - Genomics

JF - Genomics

IS - 4

ER -

Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

Abstract

Access to Document

Fingerprint

Cite this