Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC

Martin Hasselblatt; Christian Thomas; Aniello Federico; Susanne Bens; Mats Hellström; Olivera Casar-Borota; Uwe Kordes; Julia E. Neumann; Matthias Dottermusch; Fausto J. Rodriguez; Andrea C. Lo; Sylvia Cheng; Glenda Hendson; Juliette Hukin; Christian Hartmann; Arend Koch; David Capper; Reiner Siebert; Werner Paulus; Karolina Nemes; Pascal D. Johann; Michael C. Frühwald; Marcel Kool

doi:10.1111/nan.12797

Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC

Martin Hasselblatt
, Christian Thomas
, Aniello Federico
, Susanne Bens
, Mats Hellström
, Olivera Casar-Borota
, Uwe Kordes
, Julia E. Neumann
, Matthias Dottermusch
, Fausto J. Rodriguez
, Andrea C. Lo
, Sylvia Cheng
, Glenda Hendson
, Juliette Hukin
, Christian Hartmann
, Arend Koch
, David Capper
, Reiner Siebert
, Werner Paulus
, Karolina Nemes

Pascal D. Johann, Michael C. Frühwald, Marcel Kool

Group Kool

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant, is a histopathological distinct low-grade lesion encountered in older children and young adults that shows epigenetic similarity with ATRT-MYC and has the potential for malignant progression.

Original language	English
Article number	e12797
Pages (from-to)	e12797
Journal	Neuropathology and Applied Neurobiology
Volume	48
Issue number	4
DOIs	https://doi.org/10.1111/nan.12797
Publication status	Published - Jun 2022

Keywords

atypical teratoid/rhabdoid tumour
central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency
DNA methylation profiling
neuropathology
SMARCB1 Protein/genetics
Young Adult
Teratoma
Epigenesis, Genetic
Humans
Rhabdoid Tumor/pathology
Child

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10.1111/nan.12797

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Hasselblatt, M., Thomas, C., Federico, A., Bens, S., Hellström, M., Casar-Borota, O., Kordes, U., Neumann, J. E., Dottermusch, M., Rodriguez, F. J., Lo, A. C., Cheng, S., Hendson, G., Hukin, J., Hartmann, C., Koch, A., Capper, D., Siebert, R., Paulus, W., ... Kool, M. (2022). Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC. Neuropathology and Applied Neurobiology, 48(4), e12797. Article e12797. https://doi.org/10.1111/nan.12797

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title = "Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC",

abstract = "Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant, is a histopathological distinct low-grade lesion encountered in older children and young adults that shows epigenetic similarity with ATRT-MYC and has the potential for malignant progression.",

keywords = "atypical teratoid/rhabdoid tumour, central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency, DNA methylation profiling, neuropathology, SMARCB1 Protein/genetics, Young Adult, Teratoma, Epigenesis, Genetic, Humans, Rhabdoid Tumor/pathology, Child",

author = "Martin Hasselblatt and Christian Thomas and Aniello Federico and Susanne Bens and Mats Hellstr{\"o}m and Olivera Casar-Borota and Uwe Kordes and Neumann, \{Julia E.\} and Matthias Dottermusch and Rodriguez, \{Fausto J.\} and Lo, \{Andrea C.\} and Sylvia Cheng and Glenda Hendson and Juliette Hukin and Christian Hartmann and Arend Koch and David Capper and Reiner Siebert and Werner Paulus and Karolina Nemes and Johann, \{Pascal D.\} and Fr{\"u}hwald, \{Michael C.\} and Marcel Kool",

note = "{\textcopyright} 2022 The Authors. Neuropathology and Applied Neurobiology published by John Wiley \& Sons Ltd on behalf of British Neuropathological Society.",

year = "2022",

month = jun,

doi = "10.1111/nan.12797",

language = "English",

volume = "48",

pages = "e12797",

journal = " Neuropathology and Applied Neurobiology",

issn = "0305-1846",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "4",

}

Hasselblatt, M, Thomas, C, Federico, A, Bens, S, Hellström, M, Casar-Borota, O, Kordes, U, Neumann, JE, Dottermusch, M, Rodriguez, FJ, Lo, AC, Cheng, S, Hendson, G, Hukin, J, Hartmann, C, Koch, A, Capper, D, Siebert, R, Paulus, W, Nemes, K, Johann, PD, Frühwald, MC & Kool, M 2022, 'Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC', Neuropathology and Applied Neurobiology, vol. 48, no. 4, e12797, pp. e12797. https://doi.org/10.1111/nan.12797

Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC. / Hasselblatt, Martin; Thomas, Christian; Federico, Aniello et al.
In: Neuropathology and Applied Neurobiology, Vol. 48, No. 4, e12797, 06.2022, p. e12797.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant

T2 - A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC

AU - Hasselblatt, Martin

AU - Thomas, Christian

AU - Federico, Aniello

AU - Bens, Susanne

AU - Hellström, Mats

AU - Casar-Borota, Olivera

AU - Kordes, Uwe

AU - Neumann, Julia E.

AU - Dottermusch, Matthias

AU - Rodriguez, Fausto J.

AU - Lo, Andrea C.

AU - Cheng, Sylvia

AU - Hendson, Glenda

AU - Hukin, Juliette

AU - Hartmann, Christian

AU - Koch, Arend

AU - Capper, David

AU - Siebert, Reiner

AU - Paulus, Werner

AU - Nemes, Karolina

AU - Johann, Pascal D.

AU - Frühwald, Michael C.

AU - Kool, Marcel

PY - 2022/6

Y1 - 2022/6

N2 - Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant, is a histopathological distinct low-grade lesion encountered in older children and young adults that shows epigenetic similarity with ATRT-MYC and has the potential for malignant progression.

AB - Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant, is a histopathological distinct low-grade lesion encountered in older children and young adults that shows epigenetic similarity with ATRT-MYC and has the potential for malignant progression.

KW - atypical teratoid/rhabdoid tumour

KW - central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency

KW - DNA methylation profiling

KW - neuropathology

KW - SMARCB1 Protein/genetics

KW - Young Adult

KW - Teratoma

KW - Epigenesis, Genetic

KW - Humans

KW - Rhabdoid Tumor/pathology

KW - Child

UR - https://www.scopus.com/pages/publications/85124709336

U2 - 10.1111/nan.12797

DO - 10.1111/nan.12797

M3 - Article

C2 - 35152461

AN - SCOPUS:85124709336

SN - 0305-1846

VL - 48

SP - e12797

JO - Neuropathology and Applied Neurobiology

JF - Neuropathology and Applied Neurobiology

IS - 4

M1 - e12797

ER -

Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC

Abstract

Keywords

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