Lymphoid and myeloid immune cell reconstitution after nicotinamide-expanded cord blood transplantation

Coco de Koning, Weiyang Tao, Amelia Lacna, Karin van Veghel, Mitchell E. Horwitz, Guillermo Sanz, Madan H. Jagasia, John E. Wagner, Patrick J. Stiff, Rabi Hanna, Daniela Cilloni, David Valcárcel, Tony Peled, Einat Galamidi Cohen, Uri Goshen, Aridaman Pandit, Caroline A. Lindemans, Jaap Jan Boelens, Stefan Nierkens

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Omidubicel (nicotinamide-expanded cord blood) is a potential alternative source for allogeneic hematopoietic cell transplantation (HCT) when an HLA-identical donor is lacking. A phase I/II trial with standalone omidubicel HCT showed rapid and robust neutrophil and platelet engraftment. In this study, we evaluated the immune reconstitution (IR) of patients receiving omidubicel grafts during the first 6 months post-transplant, as IR is critical for favorable outcomes of the procedure. Data was collected from the omidubicel phase I-II international, multicenter trial. The primary endpoint was the probability of achieving adequate CD4+ T-cell IR (CD4IR: > 50 × 106/L within 100 days). Secondary endpoints were the recovery of T-cells, natural killer (NK)-cells, B-cells, dendritic cells (DC), and monocytes as determined with multicolor flow cytometry. LOESS-regression curves and cumulative incidence plots were used for data description. Thirty-six omidubicel recipients (median 44; 13–63 years) were included, and IR data was available from 28 recipients. Of these patients, 90% achieved adequate CD4IR. Overall, IR was complete and consisted of T-cell, monocyte, DC, and notably fast NK- and B-cell reconstitution, compared to conventional grafts. Our data show that transplantation of adolescent and adult patients with omidubicel results in full and broad IR, which is comparable with IR after HCT with conventional graft sources.

Original languageEnglish
Pages (from-to)2826-2833
Number of pages8
JournalBone Marrow Transplantation
Volume56
Issue number11
DOIs
Publication statusPublished - Nov 2021

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