Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study

A C Lambrechts, L H Looijenga, M B van't Veer, J van Echten, W Timens, J W Oosterhuis

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24 Citations (Scopus)

Abstract

The presence of the BCL-2 protein was studied in nine non-Hodgkin's lymphomas with testicular localisation. A consistent presence of the BCL-2 protein was found. The chromosomal translocation (14;18) was seen neither by cytogenetic analysis (n = 4) nor by polymerase chain reaction amplification and Southern blotting (n = 9). Therefore, this translocation is not responsible for the presence of the BCL-2 protein in non-Hodgkin's lymphomas with testicular localisation. We suggest that the presence of the BCL-2 protein in these lymphomas is related to the differentiation stage of the B-lymphocytes or may play a role in the pathogenesis of these lymphomas. The consistent finding of the BCL-2 protein in lymphomas with testicular localisation may support the clinical observation that these lymphomas are a separate entity.

Original languageEnglish
Pages (from-to)73-7
Number of pages5
JournalBritish journal of cancer
Volume71
Issue number1
DOIs
Publication statusPublished - Jan 1995
Externally publishedYes

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Base Sequence
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 18
  • Humans
  • Immunohistochemistry
  • Lymphoma, Non-Hodgkin/chemistry
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Proto-Oncogene Proteins/analysis
  • Proto-Oncogene Proteins c-bcl-2
  • Testicular Neoplasms/chemistry
  • Translocation, Genetic

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