Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study

A C Lambrechts; L H Looijenga; M B van't Veer; J van Echten; W Timens; J W Oosterhuis

doi:10.1038/bjc.1995.15

Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study

A C Lambrechts
, L H Looijenga
, M B van't Veer
, J van Echten
, W Timens
, J W Oosterhuis

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The presence of the BCL-2 protein was studied in nine non-Hodgkin's lymphomas with testicular localisation. A consistent presence of the BCL-2 protein was found. The chromosomal translocation (14;18) was seen neither by cytogenetic analysis (n = 4) nor by polymerase chain reaction amplification and Southern blotting (n = 9). Therefore, this translocation is not responsible for the presence of the BCL-2 protein in non-Hodgkin's lymphomas with testicular localisation. We suggest that the presence of the BCL-2 protein in these lymphomas is related to the differentiation stage of the B-lymphocytes or may play a role in the pathogenesis of these lymphomas. The consistent finding of the BCL-2 protein in lymphomas with testicular localisation may support the clinical observation that these lymphomas are a separate entity.

Original language	English
Pages (from-to)	73-7
Number of pages	5
Journal	British journal of cancer
Volume	71
Issue number	1
DOIs	https://doi.org/10.1038/bjc.1995.15
Publication status	Published - Jan 1995
Externally published	Yes

Keywords

Adult
Aged
Aged, 80 and over
Base Sequence
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Humans
Immunohistochemistry
Lymphoma, Non-Hodgkin/chemistry
Male
Middle Aged
Molecular Sequence Data
Proto-Oncogene Proteins/analysis
Proto-Oncogene Proteins c-bcl-2
Testicular Neoplasms/chemistry
Translocation, Genetic

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10.1038/bjc.1995.15

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title = "Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study",

abstract = "The presence of the BCL-2 protein was studied in nine non-Hodgkin's lymphomas with testicular localisation. A consistent presence of the BCL-2 protein was found. The chromosomal translocation (14;18) was seen neither by cytogenetic analysis (n = 4) nor by polymerase chain reaction amplification and Southern blotting (n = 9). Therefore, this translocation is not responsible for the presence of the BCL-2 protein in non-Hodgkin's lymphomas with testicular localisation. We suggest that the presence of the BCL-2 protein in these lymphomas is related to the differentiation stage of the B-lymphocytes or may play a role in the pathogenesis of these lymphomas. The consistent finding of the BCL-2 protein in lymphomas with testicular localisation may support the clinical observation that these lymphomas are a separate entity.",

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author = "Lambrechts, \{A C\} and Looijenga, \{L H\} and \{van't Veer\}, \{M B\} and \{van Echten\}, J and W Timens and Oosterhuis, \{J W\}",

year = "1995",

month = jan,

doi = "10.1038/bjc.1995.15",

language = "English",

volume = "71",

pages = "73--7",

journal = "British journal of cancer",

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T1 - Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18)

T2 - a molecular and immunohistochemical study

AU - Lambrechts, A C

AU - Looijenga, L H

AU - van't Veer, M B

AU - van Echten, J

AU - Timens, W

AU - Oosterhuis, J W

PY - 1995/1

Y1 - 1995/1

N2 - The presence of the BCL-2 protein was studied in nine non-Hodgkin's lymphomas with testicular localisation. A consistent presence of the BCL-2 protein was found. The chromosomal translocation (14;18) was seen neither by cytogenetic analysis (n = 4) nor by polymerase chain reaction amplification and Southern blotting (n = 9). Therefore, this translocation is not responsible for the presence of the BCL-2 protein in non-Hodgkin's lymphomas with testicular localisation. We suggest that the presence of the BCL-2 protein in these lymphomas is related to the differentiation stage of the B-lymphocytes or may play a role in the pathogenesis of these lymphomas. The consistent finding of the BCL-2 protein in lymphomas with testicular localisation may support the clinical observation that these lymphomas are a separate entity.

AB - The presence of the BCL-2 protein was studied in nine non-Hodgkin's lymphomas with testicular localisation. A consistent presence of the BCL-2 protein was found. The chromosomal translocation (14;18) was seen neither by cytogenetic analysis (n = 4) nor by polymerase chain reaction amplification and Southern blotting (n = 9). Therefore, this translocation is not responsible for the presence of the BCL-2 protein in non-Hodgkin's lymphomas with testicular localisation. We suggest that the presence of the BCL-2 protein in these lymphomas is related to the differentiation stage of the B-lymphocytes or may play a role in the pathogenesis of these lymphomas. The consistent finding of the BCL-2 protein in lymphomas with testicular localisation may support the clinical observation that these lymphomas are a separate entity.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Base Sequence

KW - Chromosomes, Human, Pair 14

KW - Chromosomes, Human, Pair 18

KW - Humans

KW - Immunohistochemistry

KW - Lymphoma, Non-Hodgkin/chemistry

KW - Male

KW - Middle Aged

KW - Molecular Sequence Data

KW - Proto-Oncogene Proteins/analysis

KW - Proto-Oncogene Proteins c-bcl-2

KW - Testicular Neoplasms/chemistry

KW - Translocation, Genetic

UR - https://www.scopus.com/pages/publications/0028820922

U2 - 10.1038/bjc.1995.15

DO - 10.1038/bjc.1995.15

M3 - Article

C2 - 7819053

SN - 0007-0920

VL - 71

SP - 73

EP - 77

JO - British journal of cancer

JF - British journal of cancer

IS - 1

ER -

Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study

Abstract

Keywords

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