Malignant stem cells in childhood acute lymphoblastic leukemia: the stem cell concept revisited

H Josef Vormoor

doi:10.4161/cc.8.7.7984

Malignant stem cells in childhood acute lymphoblastic leukemia: the stem cell concept revisited

Research output: Contribution to journal › Article › peer-review

Abstract

We have recently shown that in childhood acute lymphoblastic leukemia (ALL) blasts at different stages of immunophenotypic maturation possess stem cell properties. Here, we discuss our results in the context of previous investigations of ALL stem cells and recent studies highlighting specific limitations of the xenotransplantation models for human hematopoietic cells. Leukemia-propagating stem cells in ALL may be more frequent than previously thought!

Original language	English
Pages (from-to)	996-9
Number of pages	4
Journal	Cell cycle (Georgetown, Tex.)
Volume	8
Issue number	7
DOIs	https://doi.org/10.4161/cc.8.7.7984
Publication status	Published - 1 Apr 2009
Externally published	Yes

Keywords

Animals
Antigens, CD19/metabolism
Antigens, CD20/metabolism
Antigens, CD34/metabolism
Hematopoietic Stem Cell Transplantation
Humans
Mice
Mice, SCID
Neoplastic Stem Cells/metabolism
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism
Transplantation, Heterologous/immunology

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title = "Malignant stem cells in childhood acute lymphoblastic leukemia: the stem cell concept revisited",

abstract = "We have recently shown that in childhood acute lymphoblastic leukemia (ALL) blasts at different stages of immunophenotypic maturation possess stem cell properties. Here, we discuss our results in the context of previous investigations of ALL stem cells and recent studies highlighting specific limitations of the xenotransplantation models for human hematopoietic cells. Leukemia-propagating stem cells in ALL may be more frequent than previously thought!",

keywords = "Animals, Antigens, CD19/metabolism, Antigens, CD20/metabolism, Antigens, CD34/metabolism, Hematopoietic Stem Cell Transplantation, Humans, Mice, Mice, SCID, Neoplastic Stem Cells/metabolism, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism, Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism, Transplantation, Heterologous/immunology",

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year = "2009",

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doi = "10.4161/cc.8.7.7984",

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T2 - the stem cell concept revisited

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AB - We have recently shown that in childhood acute lymphoblastic leukemia (ALL) blasts at different stages of immunophenotypic maturation possess stem cell properties. Here, we discuss our results in the context of previous investigations of ALL stem cells and recent studies highlighting specific limitations of the xenotransplantation models for human hematopoietic cells. Leukemia-propagating stem cells in ALL may be more frequent than previously thought!

KW - Animals

KW - Antigens, CD19/metabolism

KW - Antigens, CD20/metabolism

KW - Antigens, CD34/metabolism

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Mice

KW - Mice, SCID

KW - Neoplastic Stem Cells/metabolism

KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism

KW - Transplantation, Heterologous/immunology

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DO - 10.4161/cc.8.7.7984

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EP - 999

JO - Cell cycle (Georgetown, Tex.)

JF - Cell cycle (Georgetown, Tex.)

IS - 7

ER -

Malignant stem cells in childhood acute lymphoblastic leukemia: the stem cell concept revisited

Abstract

Keywords

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