Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study

Marc Dirix; Tine van Becelaere; Lizanne Berkenbosch; Robertine van Baren; Rene M Wijnen; Marc H Wijnen; David C van der Zee; Hugo A Heij; Joep P M Derikx; L W Ernest van Heurn

doi:10.1016/j.jpedsurg.2014.07.014

Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study

Marc Dirix, Tine van Becelaere, Lizanne Berkenbosch, Robertine van Baren, Rene M Wijnen, Marc H Wijnen, David C van der Zee, Hugo A Heij, Joep P M Derikx, L W Ernest van Heurn

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

BACKGROUND/PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance.

METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010.

RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.

Original language	English
Pages (from-to)	462-4
Number of pages	3
Journal	Journal of Pediatric Surgery
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.jpedsurg.2014.07.014
Publication status	Published - Aug 2014
Externally published	Yes

Keywords

Adolescent
Anal Canal/abnormalities
Child
Child, Preschool
Digestive System Abnormalities
Female
Humans
Infant, Newborn
Male
Neoplasm Recurrence, Local/mortality
Netherlands
Rectum/abnormalities
Retrospective Studies
Sacrococcygeal Region/pathology
Sacrum/abnormalities
Spinal Neoplasms/mortality
Syringomyelia
Teratoma/mortality

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10.1016/j.jpedsurg.2014.07.014

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Dirix, M., van Becelaere, T., Berkenbosch, L., van Baren, R., Wijnen, R. M., Wijnen, M. H., van der Zee, D. C., Heij, H. A., Derikx, J. P. M., & van Heurn, L. W. E. (2014). Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study. Journal of Pediatric Surgery, 50(3), 462-4. https://doi.org/10.1016/j.jpedsurg.2014.07.014

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title = "Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study",

abstract = "BACKGROUND/PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance.METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010.RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.",

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author = "Marc Dirix and {van Becelaere}, Tine and Lizanne Berkenbosch and {van Baren}, Robertine and Wijnen, {Rene M} and Wijnen, {Marc H} and {van der Zee}, {David C} and Heij, {Hugo A} and Derikx, {Joep P M} and {van Heurn}, {L W Ernest}",

year = "2014",

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doi = "10.1016/j.jpedsurg.2014.07.014",

language = "English",

volume = "50",

pages = "462--4",

journal = "Journal of Pediatric Surgery",

issn = "0022-3468",

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Dirix, M, van Becelaere, T, Berkenbosch, L, van Baren, R, Wijnen, RM, Wijnen, MH, van der Zee, DC, Heij, HA, Derikx, JPM & van Heurn, LWE 2014, 'Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study', Journal of Pediatric Surgery, vol. 50, no. 3, pp. 462-4. https://doi.org/10.1016/j.jpedsurg.2014.07.014

TY - JOUR

T1 - Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome

T2 - a comparative study

AU - Dirix, Marc

AU - van Becelaere, Tine

AU - Berkenbosch, Lizanne

AU - van Baren, Robertine

AU - Wijnen, Rene M

AU - Wijnen, Marc H

AU - van der Zee, David C

AU - Heij, Hugo A

AU - Derikx, Joep P M

AU - van Heurn, L W Ernest

PY - 2014/8

Y1 - 2014/8

N2 - BACKGROUND/PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance.METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010.RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.

AB - BACKGROUND/PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance.METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010.RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.

KW - Adolescent

KW - Anal Canal/abnormalities

KW - Child

KW - Child, Preschool

KW - Digestive System Abnormalities

KW - Female

KW - Humans

KW - Infant, Newborn

KW - Male

KW - Neoplasm Recurrence, Local/mortality

KW - Netherlands

KW - Rectum/abnormalities

KW - Retrospective Studies

KW - Sacrococcygeal Region/pathology

KW - Sacrum/abnormalities

KW - Spinal Neoplasms/mortality

KW - Syringomyelia

KW - Teratoma/mortality

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U2 - 10.1016/j.jpedsurg.2014.07.014

DO - 10.1016/j.jpedsurg.2014.07.014

M3 - Article

C2 - 25746708

SN - 0022-3468

VL - 50

SP - 462

EP - 464

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

IS - 3

ER -

Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study

Abstract

Keywords

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